| Literature DB >> 21699963 |
Inamullah Khan1, Muhammad Nisar, Muhammad Raza Shah, Hamidullah Shah, Syed Naeemuddin Gilani, Farah Gul, Syed Muhammad Abdullah, Mohammad Ismail, Nematullah Khan, Waqar Ahmad Kaleem, Mughal Qayum, Haroon Khan, Majeed Ullah.
Abstract
Current study was conducted to identify constituents of Taxus wallichiana Zucc. that might be responsible for its folk use in anti-inflammatory conditions. Taxusabietane A was isolated from the bark extract of Taxus wallichiana Zucc. Taxusabietane A was analyzed for in-vitro and in-vivo anti-inflammatory activities using Lipoxygenase (LOX) inhibition assay and carrageenan-induced paw edema model. Taxusabietane A revealed considerable LOX inhibitory activity with the IC(50) value being 57 ± 0.31. Standard compound Baicalein showed the IC(50) value being 22.1 ± 0.03 μM. Taxusabietane A also showed significant (5 and 10 mg/kg) anti-inflammatory activity induced by carrageenan. However, this study highlighted the potential of Taxusabietane A to be further explored as a new lead compound for management of conditions associated with inflammation.Entities:
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Year: 2011 PMID： 21699963 DOI： 10.1016/j.fitote.2011.06.003
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882