Literature DB >> 21699800

The importance of the gastrointestinal tract in the control of bone mass accrual.

Gerard Karsenty1, Michael D Gershon.   

Abstract

One of the least anticipated and less heralded outcomes of mouse genetics has been to rediscover whole organism physiology. Among the many unexpected findings that it has brought to our attention has been the realization that gut-derived serotonin is a hormone-inhibiting bone formation. The importance of this discovery presented in this review is 2-fold. First, it provides a molecular explanation for 2 human genetic diseases-osteoporosis, pseudoglioma, and high bone mass syndrome; second, it suggests a novel and anabolic way to treat osteoporosis. These findings illustrate the importance of the gastrointestinal tract in the regulation of organ physiology at yet another extraluminal site.
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21699800      PMCID： PMC4902797          DOI： 10.1053/j.gastro.2011.06.011

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  38 in total

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8.  Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis.

Authors:  Vijay K Yadav; Santhanam Balaji; Padmanaban S Suresh; X Sherry Liu; Xin Lu; Zhishan Li; X Edward Guo; J John Mann; Anil K Balapure; Michael D Gershon; Rudraiah Medhamurthy; Marc Vidal; Gerard Karsenty; Patricia Ducy
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10.  Endocrine regulation of energy metabolism by the skeleton.

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Journal:  Cell       Date:  2007-08-10       Impact factor: 41.582
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  8 in total

Review 1.  Type 2 diabetes and bone fractures.

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2.  Selective inhibition of intestinal 5-HT improves neurobehavioral abnormalities caused by high-fat diet mice.

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4.  Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells.

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6.  Identification of 5-hydroxytryptamine-producing cells by detection of fluorescence in paraffin-embedded tissue sections.

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7.  Aberrant tryptophan transport in cultured fibroblast from patients with Male Idiopathic Osteoporosis: An in vitro study.

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Review 8.  Perspective on skeletal health in inflammatory bowel disease.

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  8 in total

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