Literature DB >> 21697957

Gold nanoparticle-mediated gene delivery induces widespread changes in the expression of innate immunity genes.

E-Y Kim1, R Schulz, P Swantek, K Kunstman, M H Malim, S M Wolinsky.   

Abstract

The unique properties of oligonucleotide (and small interfering RNA)-modified gold nanoparticle conjugates make them promising intracellular gene regulation agents. We found that gold nanoparticles stably functionalized with covalently attached oligonucleotides activate immune-related genes and pathways in human peripheral blood mononuclear cells, but not an immortalized, lineage-restricted cell line. These findings have strong implications for the application of oligonucleotide-modified gold nanoparticle conjugates in translational research and in the development of therapeutics and gene delivery systems.

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Year:  2011        PMID： 21697957     DOI： 10.1038/gt.2011.95

Source DB:  PubMed          Journal:  Gene Ther        ISSN： 0969-7128            Impact factor:   5.250


  16 in total

Review 1.  Drug targeting to infectious diseases by nanoparticles surface functionalized with special biomolecules.

Authors:  Shyam Sundar; Vijay Kumar Prajapati
Journal:  Curr Med Chem       Date:  2012       Impact factor: 4.530

2.  Unexpected intracellular biodegradation and recrystallization of gold nanoparticles.

Authors:  Alice Balfourier; Nathalie Luciani; Guillaume Wang; Gerald Lelong; Ovidiu Ersen; Abdelali Khelfa; Damien Alloyeau; Florence Gazeau; Florent Carn
Journal:  Proc Natl Acad Sci U S A       Date:  2019-12-18       Impact factor: 11.205

Review 3.  Biological monitoring of workers exposed to engineered nanomaterials.

Authors:  P Schulte; V Leso; M Niang; I Iavicoli
Journal:  Toxicol Lett       Date:  2018-06-18       Impact factor: 4.372

4.  In vivo gold nanoparticle delivery of peptide vaccine induces anti-tumor immune response in prophylactic and therapeutic tumor models.

Authors:  Aaron Edward Foster; Rebekah Anna Drezek; Joao Paulo Mattos Almeida; Adam Yuh Lin; Elizabeth Raquel Figueroa
Journal:  Small       Date:  2014-10-29       Impact factor: 13.281

5.  Theranostic agents for intracellular gene delivery with spatiotemporal imaging.

Authors:  Jennifer M Knipe; Jonathan T Peters; Nicholas A Peppas
Journal:  Nano Today       Date:  2013-02-01       Impact factor: 20.722

Review 6.  Multifunctional gold nanoparticles for diagnosis and therapy of disease.

Authors:  Aneta J Mieszawska; Willem J M Mulder; Zahi A Fayad; David P Cormode
Journal:  Mol Pharm       Date:  2013-02-11       Impact factor: 4.939

Review 7.  Environmental Immunology: Lessons Learned from Exposure to a Select Panel of Immunotoxicants.

Authors:  Joanna M Kreitinger; Celine A Beamer; David M Shepherd
Journal:  J Immunol       Date:  2016-04-15       Impact factor: 5.422

Review 8.  Gold nanoparticle mediated cancer immunotherapy.

Authors:  Joao Paulo Mattos Almeida; Elizabeth Raquel Figueroa; Rebekah Anna Drezek
Journal:  Nanomedicine       Date:  2013-10-05       Impact factor: 5.307

Review 9.  Synergies between therapeutic ultrasound, gene therapy and immunotherapy in cancer treatment.

Authors:  Nisi Zhang; James Wang; Josquin Foiret; Zhifei Dai; Katherine W Ferrara
Journal:  Adv Drug Deliv Rev       Date:  2021-07-30       Impact factor: 15.470

10.  Terminal PEGylated DNA-Gold Nanoparticle Conjugates Offering High Resistance to Nuclease Degradation and Efficient Intracellular Delivery of DNA Binding Agents.

Authors:  Lei Song; Yuan Guo; Deborah Roebuck; Chun Chen; Min Yang; Zhongqiang Yang; Sreejesh Sreedharan; Caroline Glover; Jim A Thomas; Dongsheng Liu; Shengrong Guo; Rongjun Chen; Dejian Zhou
Journal:  ACS Appl Mater Interfaces       Date:  2015-08-13       Impact factor: 9.229
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