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Literature DB >> 2169730

Transforming growth-factor-beta (TGF-beta) inhibits albumin synthesis in normal human hepatocytes and in hepatoma HepG2 cells.

N Busso¹, C Chesne, F Delers, F Morel, A Guillouzo.

Abstract

We explored the effect of transforming growth factor beta (TGF-beta), a cytokine that appears to play a central role in inflammatory events, on albumin expression by normal adult human hepatocytes and hepatoma cells. Addition of TGF-beta to primary human hepatocyte cultures resulted in a dramatic decrease in albumin accumulation and synthesis. This effect was dose-dependent, took place after a 48h incubation period and was maintained over 96h. TGF-beta-decreased albumin protein levels were associated with reduced albumin mRNA content. Actin mRNA levels were concomittantly increased. Comparable qualitative effects of TGF-beta were observed on human hepatoma HepG2 cells.

Entities: Disease Gene Species

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Year: 1990 PMID： 2169730 DOI： 10.1016/0006-291x(90)91195-x

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

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Transforming growth-factor-beta (TGF-beta) inhibits albumin synthesis in normal human hepatocytes and in hepatoma HepG2 cells.

1. Cytokine-induced hypoalbuminemia in a patient with hemophagocytic syndrome: direct in vitro evidence for the role of tumor necrosis factor-alpha.

2. Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells.

3. Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues.

4. Exploiting maleimide-functionalized hyaluronan hydrogels to test cellular responses to physical and biochemical stimuli.

5. Transforming growth factor (TGF)-beta stimulates hepatic jun-B and fos-B proto-oncogenes and decreases albumin mRNA.

6. Characterization of a serum factor that decreases albumin mRNA in cultured hepatocytes.

7. Real-time monitoring of liver fibrosis through embedded sensors in a microphysiological system.