Literature DB >> 2169729

Induction and stimulation of 92-kDa gelatinase/type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor alpha.

Y Okada1, H Tsuchiya, H Shimizu, K Tomita, I Nakanishi, H Sato, M Seiki, K Yamashita, T Hayakawa.   

Abstract

Production of a 92-kDa gelatinase/type IV collagenase and tissue inhibitor of metalloproteinases (TIMP) was investigated with human sarcoma cell lines. Among the cytokines and growth factors examined, only human recombinant tumor necrosis factor alpha (TNF alpha) induced and stimulated the proteinase with concomitant increase in TIMP expression, but matrix metalloproteinase 2 (72-kDa gelatinase/type IV collagenase) expression was unchanged. These data suggest that gene expression of the two metalloproteinases is regulated in a different fashion and TNF alpha may be important to allow cancer cells to be more invasive and metastatic.

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Year:  1990        PMID： 2169729     DOI： 10.1016/0006-291x(90)91190-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  42 in total

Review 1.  Cytokines as biological response modifiers.

Authors:  R C Rees
Journal:  J Clin Pathol       Date:  1992-02       Impact factor: 3.411

2.  Expression of metalloproteinases endometrial stromal sarcoma: immunohistochemical study using image analysis.

Authors:  P Liokumovich; I Goldberg; B Davidson; W H Gotlieb; T Zahavi; G Ben-Baruch; I Reder; J Kopolovic
Journal:  J Clin Pathol       Date:  1999-03       Impact factor: 3.411

Review 3.  The matrix metalloproteinases and their inhibitors in pancreatic cancer. From molecular science to a clinical application.

Authors:  S R Bramhall
Journal:  Int J Pancreatol       Date:  1997-02

4.  Unravelling the antimetastatic potential of pentoxifylline, a methylxanthine derivative in human MDA-MB-231 breast cancer cells.

Authors:  Peeyush N Goel; R P Gude
Journal:  Mol Cell Biochem       Date:  2011-07-03       Impact factor: 3.396

5.  Antioxidants inhibit TNFalpha-induced motility and invasion of human osteosarcoma cells: possible involvement of NFkappaB activation.

Authors:  K Harimaya; K Tanaka; Y Matsumoto; H Sato; S Matsuda; Y Iwamoto
Journal:  Clin Exp Metastasis       Date:  2000       Impact factor: 5.150

6.  Langerhans' cells produce type IV collagenase (MMP-9) following epicutaneous stimulation with haptens.

Authors:  Y Kobayashi
Journal:  Immunology       Date:  1997-04       Impact factor: 7.397

7.  Correlated expression of matrix metalloproteinases and ets family transcription factor E1A-F in invasive oral squamous-cell-carcinoma-derived cell lines.

Authors:  M Shindoh; F Higashino; M Kaya; M Yasuda; K Funaoka; M Hanzawa; K Hida; T Kohgo; A Amemiya; K Yoshida; K Fujinaga
Journal:  Am J Pathol       Date:  1996-03       Impact factor: 4.307

8.  Expression of matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) induced by tumour necrosis factor alpha correlates with metastatic ability in a human osteosarcoma cell line.

Authors:  A Kawashima; I Nakanishi; H Tsuchiya; A Roessner; K Obata; Y Okada
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064

9.  Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.

Authors:  E J Bernhard; S B Gruber; R J Muschel
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

10.  Expression of gelatinase A and TIMP-2 mRNAs in desmoplastic fibroblasts in both mammary carcinomas and basal cell carcinomas of the skin.

Authors:  R Poulsom; A M Hanby; M Pignatelli; R E Jeffery; J M Longcroft; L Rogers; G W Stamp
Journal:  J Clin Pathol       Date:  1993-05       Impact factor: 3.411
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