| Literature DB >> 21696955 |
Jennifer L Gage1, Rene Onrust, Derek Johnston, Andrew Osnowski, Wendy Macdonald, Lee Mitchell, László Urögdi, Alex Rohde, Kevin Harbol, Sasha Gragerov, György Dormán, Tom Wheeler, Vince Florio, Neil S Cutshall.
Abstract
Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were efficacious in animal models of schizophrenia and may be useful for the treatment of this disease.Entities:
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Year: 2011 PMID： 21696955 DOI： 10.1016/j.bmcl.2011.05.100
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823