| Literature DB >> 2169691 |
J Cao1, Y Q Zheng, T P Liu, L Z Feng.
Abstract
Rat brain microsomal Na+, K(+)-ATPase activity was inhibited significantly and rapidly by ginsenoside Rb1. The IC50 of Rb1 for Na+,K(+)-ATPase was 6.3 +/- 1.0 mumol/L. The inhibition was enhanced with increasing the concentration of Rb1 or decreasing that of Na+ and K+. Kinetic analysis revealed that ginsenoside was an uncompetitive inhibitor with respect to ATP. The inhibitory effect of Rg1 on rat brain microsomal Na+,K(+)-ATPase was much weaker than that of Rb1.Entities:
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Year: 1990 PMID： 2169691
Source DB: PubMed Journal: Zhongguo Yao Li Xue Bao ISSN： 0253-9756