Elham Hatef1, Elizabeth Colantuoni2, Jianmin Wang3, Mohamed Ibrahim1, Matthew Shulman1, Fatima Adhi1, Yasir Jamal Sepah1, Roomasa Channa1, Afsheen Khwaja1, Quan Dong Nguyen1, Diana V Do4. 1. Retinal Imaging Research and Reading Center (RIRRC), Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. 2. Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland. 3. Retinal Imaging Research and Reading Center (RIRRC), Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Ophthalmology, The Second Hospital of Hebei Medical University Shijiazhuang, Hebei Province, China. 4. Retinal Imaging Research and Reading Center (RIRRC), Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: ddo@jhmi.edu.
Abstract
PURPOSE: To investigate relationship between macular sensitivity and retinal thickness in diabetic macular edema (DME). DESIGN: Prospective observational study. METHODS: settings: University-based retina practice. patients: Twenty-two eyes of 11 patients with DME. procedure: Fundus microperimetry and retinal thickness tomography were performed simultaneously using an automatic fundus perimetry/tomography system. main outcome measures: Quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and retinal thickness. RESULTS: Fixation stability revealed that 21 eyes (95.4%) had stable fixation (>75% within central 2 degrees of point of fixation) and 1 eye (4.5%) had relatively unstable fixation (<75% of fixation points located within 2 degrees, >75% located within 4 degrees). Evaluation of fixation location revealed that 15 eyes (68.2%) had central (>50% of fixation points within 0.5 mm of fovea), 3 eyes (13.6%) pericentral (25% to 50% within 0.5 mm of fovea), and 4 eyes (18.2%) eccentric (<25% of fixation points within 0.5 mm of fovea) fixation location. Macular sensitivity increased by an average of 0.03 decibel (dB) (95% confidence interval [CI]: 0.00, 0.06) per 1-micron (μm) increase in retinal thickness for thickness values ≤280 μm measured with the OPKO/OTI spectral-domain OCT. The macular sensitivity decreased by an average 0.05 dB (95% CI: -0.08, -0.02) per 1-μm increase in thickness for thickness values >280 μm. CONCLUSIONS: In this pilot study, the majority of eyes with DME had stable, central fixation. Macular sensitivity varied depending on the thickness of the retina. Additional studies are needed to determine the role of microperimetry in eyes with DME.
PURPOSE: To investigate relationship between macular sensitivity and retinal thickness in diabetic macular edema (DME). DESIGN: Prospective observational study. METHODS: settings: University-based retina practice. patients: Twenty-two eyes of 11 patients with DME. procedure: Fundus microperimetry and retinal thickness tomography were performed simultaneously using an automatic fundus perimetry/tomography system. main outcome measures: Quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and retinal thickness. RESULTS: Fixation stability revealed that 21 eyes (95.4%) had stable fixation (>75% within central 2 degrees of point of fixation) and 1 eye (4.5%) had relatively unstable fixation (<75% of fixation points located within 2 degrees, >75% located within 4 degrees). Evaluation of fixation location revealed that 15 eyes (68.2%) had central (>50% of fixation points within 0.5 mm of fovea), 3 eyes (13.6%) pericentral (25% to 50% within 0.5 mm of fovea), and 4 eyes (18.2%) eccentric (<25% of fixation points within 0.5 mm of fovea) fixation location. Macular sensitivity increased by an average of 0.03 decibel (dB) (95% confidence interval [CI]: 0.00, 0.06) per 1-micron (μm) increase in retinal thickness for thickness values ≤280 μm measured with the OPKO/OTI spectral-domain OCT. The macular sensitivity decreased by an average 0.05 dB (95% CI: -0.08, -0.02) per 1-μm increase in thickness for thickness values >280 μm. CONCLUSIONS: In this pilot study, the majority of eyes with DME had stable, central fixation. Macular sensitivity varied depending on the thickness of the retina. Additional studies are needed to determine the role of microperimetry in eyes with DME.
Authors: E Hatef; M Hanout; A Moradi; E Colantuoni; M Bittencourt; H Liu; Y J Sepah; M Ibrahim; D V Do; D L Guyton; Q D Nguyen Journal: Eye (Lond) Date: 2014-08-08 Impact factor: 3.775
Authors: Emily S Levine; Eric M Moult; Eugenia Custo Greig; Yi Zhao; Varsha Pramil; Isaac Gendelman; Agha Y Alibhai; Caroline R Baumal; Andre J Witkin; Jay S Duker; James G Fujimoto; Nadia K Waheed Journal: Retina Date: 2022-02-01 Impact factor: 4.256
Authors: Marco U Morales; Saker Saker; Craig Wilde; Carlo Pellizzari; Aristophanes Pallikaris; Neil Notaroberto; Martin Rubinstein; Chiara Rui; Paolo Limoli; Michael K Smolek; Winfried M Amoaku Journal: Transl Vis Sci Technol Date: 2016-11-15 Impact factor: 3.283