Yang-Gyun Kim1, Se-Bin Song1, Sang-Ho Lee1, Ju-Young Moon1, Kyung-Hwan Jeong1, Tae-Won Lee1, Chun-Gyoo Ihm2,3. 1. Division of Nephrology, Kyung Hee University School of Medicine, Seoul, Korea. 2. Division of Nephrology, Kyung Hee University School of Medicine, Seoul, Korea. cgihm@yahoo.co.kr. 3. Department of Nephrology, Kyung Hee University Medical Center, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-702, Korea. cgihm@yahoo.co.kr.
Abstract
BACKGROUND: The intrarenal renin-angiotensinogen system (RAS) plays a major role in the progression of chronic kidney disease. Urinary angiotensinogen (UAGT) provides a specific index of the intrarenal RAS status. This study was conducted to find the role of UAGT as a predictive marker in patients with immunoglobulin A nephropathy (IgAN). METHODS: Thirty-six patients with IgAN, 14 non-IgAN and 15 healthy controls were included. The UAGT concentration was measured using human ELISA kits and adjusted by urinary creatinine. RESULTS: UAGT levels were significantly higher in patients with IgAN and non-IgAN than in healthy subjects (104.96 vs. 6.71 ng/mgCr, p < 0.01). Using univariate regression analysis, UAGT was found to correlate with the urine protein-to-creatinine ratio (UPCR), serum creatinine, and systolic and diastolic blood pressure in patients with IgAN. Multivariate regression analysis revealed that UAGT correlated positively with UPCR. Patients with levels of UAGT >100 ng/mgCr showed higher serum creatinine after treatment than patients with UAGT levels <100 ng/mgCr. CONCLUSION: This study showed that UAGT levels are increased and correlate positively with the UPCR in IgAN. Patients with high levels of UAGT may have poor renal function following treatment.
BACKGROUND: The intrarenal renin-angiotensinogen system (RAS) plays a major role in the progression of chronic kidney disease. Urinary angiotensinogen (UAGT) provides a specific index of the intrarenal RAS status. This study was conducted to find the role of UAGT as a predictive marker in patients with immunoglobulin A nephropathy (IgAN). METHODS: Thirty-six patients with IgAN, 14 non-IgAN and 15 healthy controls were included. The UAGT concentration was measured using human ELISA kits and adjusted by urinary creatinine. RESULTS: UAGT levels were significantly higher in patients with IgAN and non-IgAN than in healthy subjects (104.96 vs. 6.71 ng/mgCr, p < 0.01). Using univariate regression analysis, UAGT was found to correlate with the urine protein-to-creatinine ratio (UPCR), serum creatinine, and systolic and diastolic blood pressure in patients with IgAN. Multivariate regression analysis revealed that UAGT correlated positively with UPCR. Patients with levels of UAGT >100 ng/mgCr showed higher serum creatinine after treatment than patients with UAGT levels <100 ng/mgCr. CONCLUSION: This study showed that UAGT levels are increased and correlate positively with the UPCR in IgAN. Patients with high levels of UAGT may have poor renal function following treatment.
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