OBJECTIVE: Few studies have evaluated the potential association between consumption of fruit and vegetables and non-Hodgkin lymphoma (NHL) by histologic subtype, and the results of these studies have been inconsistent. METHODS: A detailed history of dietary practices and food preferences was collected using a food frequency questionnaire from 348 cases and 470 controls in a population-based, case-control study conducted in Nebraska during 1999-2002. Risk for the highest versus lowest quartile or tertile of intake was estimated by odds ratios (ORs) and 95% confidence interval (CIs). RESULTS: A lower risk of overall NHL was associated with a high intake of green leafy vegetables (OR = 0.6; CI = 0.3-1.0) and cruciferous vegetables (OR = 0.7; CI = 0.4-1.0). Analysis by subtype showed that green leafy vegetable intake was associated with a lower risk of follicular lymphoma (OR = 0.5; CI = 0.3-0.8) and diffuse large B-cell lymphoma (DLBCL) (OR = 0.5; CI = 0.3-0.9), while consumption of cruciferous vegetables was associated with a lower risk of DLBCL (OR = 0.4; CI = 0.2-0.8). No association was found with intake of total vegetables, carotene-rich vegetables, or all fruit. For nutrients, the risk of NHL overall was inversely associated with a higher intake of β-cryptoxanthin (OR = 0.6; CI = 0.4-0.9), magnesium (OR = 0.4; CI = 0.2-0.6), potassium (OR = 0.5; CI = 0.3-1.0), and fiber (OR = 0.6; CI = 0.3-1.0), but positively associated with a higher intake of retinol (OR = 1.7; CI = 1.1-2.8). Intakes of vitamin E, magnesium, and potassium were inversely associated with the risk of DLBCL. CONCLUSION: A higher intake of green leafy vegetables and cruciferous vegetables is associated with a lower risk of NHL overall, particularly follicular lymphoma and DLBCL.
OBJECTIVE: Few studies have evaluated the potential association between consumption of fruit and vegetables and non-Hodgkin lymphoma (NHL) by histologic subtype, and the results of these studies have been inconsistent. METHODS: A detailed history of dietary practices and food preferences was collected using a food frequency questionnaire from 348 cases and 470 controls in a population-based, case-control study conducted in Nebraska during 1999-2002. Risk for the highest versus lowest quartile or tertile of intake was estimated by odds ratios (ORs) and 95% confidence interval (CIs). RESULTS: A lower risk of overall NHL was associated with a high intake of green leafy vegetables (OR = 0.6; CI = 0.3-1.0) and cruciferous vegetables (OR = 0.7; CI = 0.4-1.0). Analysis by subtype showed that green leafy vegetable intake was associated with a lower risk of follicular lymphoma (OR = 0.5; CI = 0.3-0.8) and diffuse large B-cell lymphoma (DLBCL) (OR = 0.5; CI = 0.3-0.9), while consumption of cruciferous vegetables was associated with a lower risk of DLBCL (OR = 0.4; CI = 0.2-0.8). No association was found with intake of total vegetables, carotene-rich vegetables, or all fruit. For nutrients, the risk of NHL overall was inversely associated with a higher intake of β-cryptoxanthin (OR = 0.6; CI = 0.4-0.9), magnesium (OR = 0.4; CI = 0.2-0.6), potassium (OR = 0.5; CI = 0.3-1.0), and fiber (OR = 0.6; CI = 0.3-1.0), but positively associated with a higher intake of retinol (OR = 1.7; CI = 1.1-2.8). Intakes of vitamin E, magnesium, and potassium were inversely associated with the risk of DLBCL. CONCLUSION: A higher intake of green leafy vegetables and cruciferous vegetables is associated with a lower risk of NHL overall, particularly follicular lymphoma and DLBCL.
Authors: Nitin Shivappa; James R Hébert; Martina Taborelli; Maurizio Montella; Massimo Libra; Antonella Zucchetto; Anna Crispo; Maria Grimaldi; Carlo La Vecchia; Diego Serraino; Jerry Polesel Journal: Cancer Causes Control Date: 2017-05-13 Impact factor: 2.506
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Authors: Kimberly A Bertrand; Edward Giovannucci; Bernard A Rosner; Shumin M Zhang; Francine Laden; Brenda M Birmann Journal: Am J Clin Nutr Date: 2017-06-28 Impact factor: 7.045
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Authors: Kimberly A Bertrand; Edward Giovannucci; Shumin M Zhang; Francine Laden; Bernard Rosner; Brenda M Birmann Journal: Cancer Prev Res (Phila) Date: 2013-06-26
Authors: José Carlos Flores; Esther Gracia-Lavedan; Yolanda Benavente; Pilar Amiano; Dora Romaguera; Laura Costas; Claudia Robles; Eva Gonzalez-Barca; Esmeralda de la Banda; Esther Alonso; Marta Aymerich; Elias Campo; Trinidad Dierssen-Sotos; Rafael Marcos-Gragera; Marta María Rodriguez-Suarez; Marta Solans; Eva Gimeno; Paloma Garcia Martin; Nuria Aragones; Nitin Shivappa; James R Hébert; Marina Pollan; Manolis Kogevinas; Silvia de Sanjose; Gemma Castaño-Vinyals; Delphine Casabonne Journal: Nutrients Date: 2019-12-23 Impact factor: 5.717