OBJECTIVE: The management of treatment-resistant depression is a much debated issue. In particular, the evidence supporting the commonly suggested sequential use of antidepressants from 2 different pharmacological classes is weak. This retrospective study was undertaken to investigate whether there is a better response in nonresponders switched to a different class of antidepressants (across-class) compared with nonresponders switched to an antidepressant from the same class (within-class). METHODS: Three hundred forty patients with primary major depressive disorder were recruited in the context of a European multicenter project. Subjects whose current depressive episode had failed to respond to a first antidepressant trial of adequate dose and duration were included. RESULTS: There was no significant difference in response or remission rates between the across-class and within-class groups after controlling for possible confounders. CONCLUSIONS: In depressed nonresponders to a previous antidepressant treatment, switching to a different class of antidepressants was not associated with a better response or remission rate.
OBJECTIVE: The management of treatment-resistant depression is a much debated issue. In particular, the evidence supporting the commonly suggested sequential use of antidepressants from 2 different pharmacological classes is weak. This retrospective study was undertaken to investigate whether there is a better response in nonresponders switched to a different class of antidepressants (across-class) compared with nonresponders switched to an antidepressant from the same class (within-class). METHODS: Three hundred forty patients with primary major depressive disorder were recruited in the context of a European multicenter project. Subjects whose current depressive episode had failed to respond to a first antidepressant trial of adequate dose and duration were included. RESULTS: There was no significant difference in response or remission rates between the across-class and within-class groups after controlling for possible confounders. CONCLUSIONS: In depressed nonresponders to a previous antidepressant treatment, switching to a different class of antidepressants was not associated with a better response or remission rate.
Authors: Geoffroy Laumet; Wenjun Zhou; Robert Dantzer; Jules D Edralin; XiaoJiao Huo; David P Budac; Jason C O'Connor; Anna W Lee; Cobi J Heijnen; Annemieke Kavelaars Journal: Brain Behav Immun Date: 2017-07-11 Impact factor: 7.217
Authors: Oliver Pain; Karen Hodgson; Vassily Trubetskoy; Stephan Ripke; Victoria S Marshe; Mark J Adams; Enda M Byrne; Adrian I Campos; Tania Carrillo-Roa; Annamaria Cattaneo; Thomas D Als; Daniel Souery; Mojca Z Dernovsek; Chiara Fabbri; Caroline Hayward; Neven Henigsberg; Joanna Hauser; James L Kennedy; Eric J Lenze; Glyn Lewis; Daniel J Müller; Nicholas G Martin; Benoit H Mulsant; Ole Mors; Nader Perroud; David J Porteous; Miguel E Rentería; Charles F Reynolds; Marcella Rietschel; Rudolf Uher; Eleanor M Wigmore; Wolfgang Maier; Naomi R Wray; Katherine J Aitchison; Volker Arolt; Bernhard T Baune; Joanna M Biernacka; Guido Bondolfi; Katharina Domschke; Masaki Kato; Qingqin S Li; Yu-Li Liu; Alessandro Serretti; Shih-Jen Tsai; Gustavo Turecki; Richard Weinshilboum; Andrew M McIntosh; Cathryn M Lewis Journal: Biol Psychiatry Glob Open Sci Date: 2022-04
Authors: Antoni Sicras-Mainar; Jorge Maurino; Luis Cordero; Milagrosa Blanca-Tamayo; Ruth Navarro-Artieda Journal: Ann Gen Psychiatry Date: 2012-08-03 Impact factor: 3.455