J Xiao1, X Zhu, G Y Hao, Y C Zhu, L L Ma, Y H Zhang, Y Tian. 1. Department of Urology, Beijing Friendship Hospital Affiliate of Capital Medical University, XuanWu District, Beijing, China.
Abstract
OBJECTIVE: To explore the association between urothelial carcinoma following renal transplantation and infection by human papillomavirus (HPV) types 16 and 18. MATERIALS AND METHODS: Of 3780 patients who underwent renal transplantation, we identified 90 cases of urothelial carcinoma. Tumor tissues collected from the 90 renal transplant recipients were compared with those from 30 nontransplanted patients with bladder cancer (control group) for HPV types 16 and 18 using polymerase chain reactions. RESULTS: Seven transplanted patients were HPV positive: HPV-16 was detected in 3 patients with bladder cancer (3/90; 3.3%), and HPV-18 in 2 patients with bilateral pelvic ureteral carcinoma (2/90; 2.2%), and 2 patients with bladder cancer (2/90; 2.2%). Only 2 cases from the control group were HPV positive (both HPV-18; 2/30; 5%). The difference between the RTR and control groups was not significant (P > .05). CONCLUSION: Malignant tumors in the urinary system following renal transplantation did not seems to be associated with infection by HPV-16 or -18.
OBJECTIVE: To explore the association between urothelial carcinoma following renal transplantation and infection by human papillomavirus (HPV) types 16 and 18. MATERIALS AND METHODS: Of 3780 patients who underwent renal transplantation, we identified 90 cases of urothelial carcinoma. Tumor tissues collected from the 90 renal transplant recipients were compared with those from 30 nontransplanted patients with bladder cancer (control group) for HPV types 16 and 18 using polymerase chain reactions. RESULTS: Seven transplanted patients were HPV positive: HPV-16 was detected in 3 patients with bladder cancer (3/90; 3.3%), and HPV-18 in 2 patients with bilateral pelvic ureteral carcinoma (2/90; 2.2%), and 2 patients with bladder cancer (2/90; 2.2%). Only 2 cases from the control group were HPV positive (both HPV-18; 2/30; 5%). The difference between the RTR and control groups was not significant (P > .05). CONCLUSION:Malignant tumors in the urinary system following renal transplantation did not seems to be associated with infection by HPV-16 or -18.
Authors: Vital Hevia; Victoria Gómez; Sara Alvarez; Víctor Díez Nicolás; Carmen Gómez Del Cañizo; Andrea Orosa; Cristina Galeano Álvarez; F J Burgos Revilla Journal: Case Rep Transplant Date: 2013-05-26