Literature DB >> 2169324

Involvement of histaminergic neurons in arousal mechanisms demonstrated with H3-receptor ligands in the cat.

J S Lin1, K Sakai, G Vanni-Mercier, J M Arrang, M Garbarg, J C Schwartz, M Jouvet.   

Abstract

The effects of histamine H3-receptor ligands on sleep-waking parameters were studied in freely moving cats. Oral administration of (R)alpha-methylhistamine (alpha MHA), a H3-agonist, caused a significant increase in deep slow wave sleep while that of thioperamide, a H3-antagonist, enhanced wakefulness in a marked and dose-dependent manner. The arousal effects of thioperamide were prevented by pretreatment with alpha MHA or mepyramine, a H1-receptor antagonist. The findings support the hypothesis that the histaminergic neurons are critically involved in arousal mechanisms and suggest that H3-receptors play an active part in these mechanisms by regulating histamine transmission.

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Year:  1990        PMID： 2169324     DOI： 10.1016/0006-8993(90)91508-e

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  30 in total

1.  Protean agonism at histamine H3 receptors in vitro and in vivo.

Authors:  Florence Gbahou; Agnès Rouleau; Séverine Morisset; Régis Parmentier; Sylvain Crochet; Jian-Sheng Lin; Xavier Ligneau; Joël Tardivel-Lacombe; Holger Stark; Walter Schunack; C Robin Ganellin; Jean-Charles Schwartz; Jean-Michel Arrang
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-05       Impact factor: 11.205

Review 2.  Retinopetal axons in mammals: emphasis on histamine and serotonin.

Authors:  Matthew J Gastinger; Ning Tian; Tamas Horvath; David W Marshak
Journal:  Curr Eye Res       Date:  2006 Jul-Aug       Impact factor: 2.424

3.  H3 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing retrieval.

Authors:  Vincent Pascoli; Corinne Boer-Saccomani; Jean-François Hermant
Journal:  Psychopharmacology (Berl)       Date:  2008-05-22       Impact factor: 4.530

4.  Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat.

Authors:  J E Sherin; J K Elmquist; F Torrealba; C B Saper
Journal:  J Neurosci       Date:  1998-06-15       Impact factor: 6.167

5.  Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype.

Authors:  Kazuhiko Takahashi; Hiroaki Suwa; Tomoo Ishikawa; Hidehito Kotani
Journal:  J Clin Invest       Date:  2002-12       Impact factor: 14.808

Review 6.  Sleep neurobiology from a clinical perspective.

Authors:  Rodrigo A España; Thomas E Scammell
Journal:  Sleep       Date:  2011-07-01       Impact factor: 5.849

7.  Histaminergic modulation of neocortical spindling and slow-wave activity in freely behaving rats.

Authors:  A Valjakka; J Vartiainen; H Kosunen; M Hippeläinen; P Pesola; H Olkkonen; M M Airaksinen; L Tuomisto
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

Review 8.  Control of sleep and wakefulness.

Authors:  Ritchie E Brown; Radhika Basheer; James T McKenna; Robert E Strecker; Robert W McCarley
Journal:  Physiol Rev       Date:  2012-07       Impact factor: 37.312

9.  Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice.

Authors:  Zhi-Li Huang; Takatoshi Mochizuki; Wei-Min Qu; Zong-Yuan Hong; Takeshi Watanabe; Yoshihiro Urade; Osamu Hayaishi
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-13       Impact factor: 11.205

10.  Modafinil in the treatment of excessive sleepiness.

Authors:  Jonathan R L Schwartz
Journal:  Drug Des Devel Ther       Date:  2009-02-06       Impact factor: 4.162
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