| Literature DB >> 21693060 |
Guy W Scott1, Helen M Scott, Karyn M O'Keeffe, Philippa H Gander.
Abstract
BACKGROUND: Insomnia is perhaps the most common sleep disorder in the general population, and is characterised by a range of complaints around difficulties in initiating and maintaining sleep, together with impaired waking function. There is little quantitative information on treatment pathways, costs and outcomes. The aims of this New Zealand study were to determine from which healthcare practitioners patients with insomnia sought treatment, treatment pathways followed, the net costs of treatment and the quality of life improvements obtained.Entities:
Year: 2011 PMID: 21693060 PMCID: PMC3152521 DOI: 10.1186/1478-7547-9-10
Source DB: PubMed Journal: Cost Eff Resour Alloc ISSN: 1478-7547
Figure 1Methodological steps.
Figure 2Decision tree descriptions of calculations. (1) Decision tree cost = the sum of all pathway costs (2) Cost of an event = the sum of (the unit costs of all resources utilised by the event multiplied by the volume of resources utilised) (3) Probability of a pathway = (pE1 × pE2 ... xpEI ... xpEn) where EI = eventI, and n = the total number of events in the pathway (4) Cost of a pathway = the sum of the cost of all events in pathway (5) A decision tree enables a method of modelling, in chronological order, all possible events (6) Resources = consultations, medicines, and transport, E = event, p = probability (7) ● = Chance node which has a branch for each possible outcome or event. Each event ha s an associated probability and value. (8) ◀= End node which does not have any succeeding braches. Each end node returns a probability and a value for the associated pathway. Upper value = probability of reaching the end point of the pathway. Lower value = cost incurred in reaching the end point of the pathway.
Unit resource cost estimates in 2009 NZ dollars
| Resource | Base case $ | Year of data | Notes |
|---|---|---|---|
| General Practitioner | 48.89 | 2009 | (1) |
| Specialist Physician initial | 222.22 | 2009 | (1) |
| Specialist Physician follow up | 99.56 | 2009 | (1) |
| Psychologist | 88.89 | 2009 | (1) |
| Health Practitioner | 120.00 | 2009 | (1) |
| Alternative Health Practitioner | 75.56 | 2008 | (2) |
| Prescription medicine | 6.42 | 2009 | (3) |
| Non prescription medicine | 16.00 | 2009 | (4) |
| Increase in cost per capita for those with insomnia versus non-insomniacs | 627.52 | 2008 | (5) |
| Transport for treatment (round trip) | 16.71 | 2009 | (6) |
Notes:
(1) Registered health care providers [40]. General Practitioner, medical practitioner band 1. Specialist Physician, medical practitioner band 2; high case (interviews). The medical fees do not include any government patient subsidy as this varies between providers and patients.
(2) Alternative Health Practitioner from Interviews
(3) Prescription medicine, Zopiclone, base case 7.5 mg @ 30 days plus dispensing fee, low case = base case × 0.5 plus dispensing fee, high case = two prescriptions plus 2 dispensing fees (Interviews) and dispensing fee [39], prices [33]
(4) Non prescription medicine (Interviews) and [34], low case = base case less 25%, high case = base case × 2
(5) See Table 3
(6) Transport for treatment: Cost per km × km travelled for round trip = $0.63/9 × 8 × 29.83 km = $16.71. [Cost per km $0.63/9 × 8: 1500-2000 cc petrol: [35]. Time to hospital (17.9 minutes): [36]. Distance for round trip (km): 17.9 minutes @ 50 km/hour × 2 = 29.83 km.]
Ranges: if not specifically stated ranges = base case plus or minus 25%
All costs have had GST of 12.5% deducted and calculations are based on unrounded data.
Figure 3Insomnia treatment model.
Resource utilisations by event
| Events | (a) | (b) | (c) | (d) | (e) | (f) | (g) | (h) | (i) |
|---|---|---|---|---|---|---|---|---|---|
| Do not seek treatment | |||||||||
| Seek treatment | |||||||||
| 1.0 | 1.0 | ||||||||
| 1.1 Refer General Practitioner | 1.0 | 1.0 | 1.0 | ||||||
| 1.2 Success | |||||||||
| 1.0 | 1.0 | ||||||||
| 2.1 No further action | |||||||||
| 2.2 Treat | 1.0 | ||||||||
| 2.2.1 Success | |||||||||
| 2.2.2 Refer | |||||||||
| 2.2.2.1 Psychologist | 4.0 | 4.0 | |||||||
| 2.2.2.2 Specialist Physician | 1.0 | 1.0 | 1.0 | 2.0 | |||||
| 2.2.2.3 Health Practitioner | 2.0 | 2.0 | |||||||
| 1.0 | 1.0 | ||||||||
| 3.1 No further action | |||||||||
| 3.2 Treat | 0.5 | ||||||||
| 3.2.1 Success | |||||||||
| 3.2.2 Refer | |||||||||
| 3.2.2.1 Psychologist | 4.0 | 4.0 | |||||||
| 3.2.2.2 Specialist Physician | 1.0 | 1.0 | 1.0 | 2.0 | |||||
| 3.2.2.3 General Practitioner | 1.0 | 1.0 | 1.0 | ||||||
| 3.2.2.4 Other Health Practitioner | 3.0 | 0.5 | 3.0 | ||||||
| 1.0 | 1.0 | ||||||||
| 4.1 No further action | |||||||||
| 4.2 Treat | |||||||||
| 4.2.1 Success | |||||||||
| 4.2.2 Refer/no further action | |||||||||
| 4.2.2.1 Other Psychologist | 4.0 | 4.0 | |||||||
| 4.2.2.2 Specialist Physician | 1.0 | 1.0 | 1.0 | 2.0 | |||||
| 4.2.2.3 General Practitioner | 1.0 | 1.0 | 1.0 | ||||||
| 4.2.2.4 No further action | |||||||||
| 1.0 | 1.0 | ||||||||
| 5.1 No further action | |||||||||
| 5.2 Treat | 2.0 | 2.0 | |||||||
| 5.2.2 Success | |||||||||
| 5.2.3 Refer/no further action | |||||||||
| 5.2.3.1 Other Alternative Health Practitioner | 2.0 | 2.0 | |||||||
| 5.2.3.2 General Practitioner | 1.0 | 1.0 | |||||||
| 5.2.3.3 No further action |
Notes:
Events: (a) General Practitioner consultation, (b) Specialist Physician Initial consultation, (c) Specialist Physician follow-up consultation, (d) Psychologist consultation, (e) Health Practitioner consultation, (f) Alternative Health Practitioner consultation, (g) Prescription medicine, (h) Non prescription medicine, (i) Transport for treatment (round trip)
Base case values were derived from the current study. Monte Carlo simulation runs used base case, and ranges base case plus or minus 25%.
Health care cost of those with insomnia versus non-insomniacs
| Item | Base Case | Year of data | Notes |
|---|---|---|---|
| Per capita health care resource cost ($) of all ages New Zealand population (TP$) | 3,568 | 2008 | (1) |
| Personal medical services ($M) | 15,313 | 2008 | (2) |
| Population all ages (M) | 4.292 | 2008 | (3) |
| Proportion of New Zealand population suffering from insomnia (Ip) | 0.13 | (4) | |
| % Increase in cost per capita of those with insomnia versus non-insomniacs | 18.0% | (5) | |
| Ratio of health resource cost of those with insomnia to non-insomniacs (R) | 1.18 | (5) | |
| Mean health care resource cost ($) of non-insomniacs (Y) | 3,486 | (6) | |
| Mean health care resource cost ($) of those with insomnia (X) | 4,114 | (6) | |
| Increase in cost per capita those with insomnia versus non-insomniacs | 628 | (6) |
Notes:
Data sources
(1) = (2) ÷ (3)
(2) Personal medical services: excludes expenditure on prevention and public health, administration and insurance premiums [41].
(3) Population: Total resident population[31]
(4) [8]
(5) [14,17-20]
(6) Derivation of "Y" and "X" from "Ip" "R" and TP$
Unknown
X = Mean health care resource cost ($) of those with insomnia
Y = Mean health care resource cost ($) of non-insomniacs
Known (Statements S1, S2, S3)
(S1): Ip = Proportion of New Zealand population suffering from insomnia, [base case 0.13]
(S2): R = Ratio of health resource cost of those with insomnia to others, [base case 1.18]
(S3): TP$ = Mean health care resource cost of total all ages New Zealand population, [base case $3,568]
Solution
(S1) and (S3) may be used to derive equation (E1): TP$ = Ip × X + [(1 - Ip) × Y] (S2) may be written as equation (E2): × = R × Y
Substitute (E2) into (E1)
TP$ = [Ip × R × Y] + [(1 - Ip) × Y]
TP$ = Y × [(Ip × R) +1 - Ip)]
Solve for Y
Y = TP$/[(Ip × R) + 1 - Ip]
Using base case values as an example
Y = $3,568/[(0.13 × 1.18)+1-0.13] = $3,486
X = ($3,486 × 1.18) = $4,114
All calculations are based on unrounded data.
Economic evaluation of insomnia treatment versus no treatment
| Per person treated | NZ total million | |
|---|---|---|
| At risk population | (1) | 2.317 |
| Prevalence of insomnia | (2) | 13% |
| Proportion seeking treatment | (2) | 15.0% |
| Number seeking treatment (M) | (3) | 0.045 |
| Costs incurred ($) | 145 | 6.6 |
| Costs avoided ($) | 628 | 28.4 |
| Net benefit ($) | 482 | 21.8 |
| QALYs gained (#) | 0.157 | 0.007 |
| Net benefit per QALY gained ($) | 3,072 | 21.8 |
Notes:
(1) December 2008 [31]
(2) [8]
Ranges (1) and (2) The high values are the base case plus 25% and the low values the base case minus 25%.
(3) = (1) × (2) × (3)
Calculations are based on unrounded data.