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Literature DB >> 21692136

Oxytocin stimulates adult neurogenesis even under conditions of stress and elevated glucocorticoids.

Benedetta Leuner¹, Julia M Caponiti, Elizabeth Gould.

Abstract

Oxytocin has been linked to social behavior, including social recognition, pair bonding and parenting, but its potential role in promoting neuronal growth has not been investigated. We show here that oxytocin, but not vasopressin, stimulates both cell proliferation and adult neurogenesis in the hippocampus of rats. Oxytocin is also capable of stimulating adult neurogenesis in rats subjected to glucocorticoid administration or cold water swim stress. These findings suggest that oxytocin stimulates neuronal growth and may protect against the suppressive effects of stress hormones on hippocampal plasticity.

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Year: 2011 PMID： 21692136 PMCID： PMC4756590 DOI： 10.1002/hipo.20947

Source DB: PubMed Journal: Hippocampus ISSN： 1050-9631 Impact factor: 3.899

61 in total

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Authors: H J Krugers; B R Douma; G Andringa; B Bohus; J Korf; P G Luiten
Journal: Hippocampus Date: 1997 Impact factor: 3.899

2. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus.

Authors: H van Praag; G Kempermann; F H Gage
Journal: Nat Neurosci Date: 1999-03 Impact factor: 24.884

3. Prevention by morphine of apomorphine- and oxytocin-induced penile erection and yawning: involvement of nitric oxide.

Authors: M R Melis; S Succu; U Iannucci; A Argiolas
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1997-05 Impact factor: 3.000

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7. Low doses of oxytocin facilitate social recognition in rats.

Authors: P Popik; J Vetulani; J M van Ree
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8. Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats.

Authors: S R Bodnoff; A G Humphreys; J C Lehman; D M Diamond; G M Rose; M J Meaney
Journal: J Neurosci Date: 1995-01 Impact factor: 6.167

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58 in total

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4. Gene-environment interaction between the oxytocin receptor (OXTR) gene and parenting behaviour on children's theory of mind.

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