OBJECTIVE: Utilizing data from the largest study to date, we examined associations between maternal preconception/prenatal exposure to household chemicals and infant acute leukemia. METHODS: We present data from a Children's Oncology Group case-control study of 443 infants (<1 year of age) diagnosed with acute leukemia [including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)] between 1996 and 2006 and 324 population controls. Mothers recalled household chemical use 1 month before and throughout pregnancy. We used unconditional logistic regression adjusted for birth year, maternal age, and race/ethnicity to calculate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: We did not find evidence for an association between infant leukemia and eight of nine chemical categories. However, exposure to petroleum products during pregnancy was associated with AML (OR = 2.54; 95% CI:1.40-4.62) and leukemia without mixed lineage leukemia (MLL) gene rearrangements ("MLL-") (OR = 2.69; 95% CI: 1.47-4.93). No associations were observed for exposure in the month before pregnancy. CONCLUSIONS: Gestational exposure to petroleum products was associated with infant leukemia, particularly AML, and MLL- cases. Benzene is implicated as a potential carcinogen within this exposure category, but a clear biological mechanism has yet to be elucidated.
OBJECTIVE: Utilizing data from the largest study to date, we examined associations between maternal preconception/prenatal exposure to household chemicals and infantacute leukemia. METHODS: We present data from a Children's Oncology Group case-control study of 443 infants (<1 year of age) diagnosed with acute leukemia [including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)] between 1996 and 2006 and 324 population controls. Mothers recalled household chemical use 1 month before and throughout pregnancy. We used unconditional logistic regression adjusted for birth year, maternal age, and race/ethnicity to calculate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: We did not find evidence for an association between infant leukemia and eight of nine chemical categories. However, exposure to petroleum products during pregnancy was associated with AML (OR = 2.54; 95% CI:1.40-4.62) and leukemia without mixed lineage leukemia (MLL) gene rearrangements ("MLL-") (OR = 2.69; 95% CI: 1.47-4.93). No associations were observed for exposure in the month before pregnancy. CONCLUSIONS: Gestational exposure to petroleum products was associated with infant leukemia, particularly AML, and MLL- cases. Benzene is implicated as a potential carcinogen within this exposure category, but a clear biological mechanism has yet to be elucidated.
Authors: Susan E Puumala; Logan G Spector; Melanie M Wall; Leslie L Robison; Nyla A Heerema; Michelle A Roesler; Julie A Ross Journal: Hum Reprod Date: 2010-04-10 Impact factor: 6.918
Authors: F E Alexander; S L Patheal; A Biondi; S Brandalise; M E Cabrera; L C Chan; Z Chen; G Cimino; J C Cordoba; L J Gu; H Hussein; E Ishii; A M Kamel; S Labra; I Q Magalhães; S Mizutani; E Petridou; M P de Oliveira; P Yuen; J L Wiemels; M F Greaves Journal: Cancer Res Date: 2001-03-15 Impact factor: 12.701
Authors: Jo Kay C Ghosh; Julia E Heck; Myles Cockburn; Jason Su; Michael Jerrett; Beate Ritz Journal: Am J Epidemiol Date: 2013-08-28 Impact factor: 4.897
Authors: Maria S Pombo-de-Oliveira; Francianne Gomes Andrade; Gisele Dallapicola Brisson; Filipe Vicente Dos Santos Bueno; Ingrid Sardou Cezar; Elda Pereira Noronha Journal: Ecancermedicalscience Date: 2017-11-30