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Literature DB >> 2168997

Myristylation of Rous sarcoma virus Gag protein does not prevent replication in avian cells.

Abstract

Rous sarcoma virus is an example of a replication-competent retrovirus whose Gag protein is not modified with myristic acid. The purpose of the experiments described in this report was to determine whether the addition of this 14-carbon fatty acid would interfere with the replication of Rous sarcoma virus. We found that myristylated derivatives of the Rous sarcoma virus Gag protein are fully functional for particle formation in avian cells and that the addition of myristic acid has very little effect on infectivity.

Entities: Chemical Gene Species

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Year: 1990 PMID： 2168997 PMCID： PMC248019 DOI： 10.1128/JVI.64.10.5204-5208.1990

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

27 in total

1. Site-directed mutagenesis of the gag-myc gene of avian myelocytomatosis virus 29: biological activity and intracellular localization of structurally altered proteins.

Authors: M L Heaney; J Pierce; J T Parsons
Journal: J Virol Date: 1986-10 Impact factor: 5.103

2. Mechanism of transfection of chicken embryo fibroblasts by Rous sarcoma virus DNA.

Authors: G M Cooper; S Okenquist
Journal: J Virol Date: 1978-10 Impact factor: 5.103

3. Myristylation site in Pr65gag is essential for virus particle formation by Moloney murine leukemia virus.

Authors: A Rein; M R McClure; N R Rice; R B Luftig; A M Schultz
Journal: Proc Natl Acad Sci U S A Date: 1986-10 Impact factor: 11.205

4. Fatty acylation of cellular proteins. Temporal and subcellular differences between palmitate and myristate acylation.

Authors: E N Olson; G Spizz
Journal: J Biol Chem Date: 1986-02-15 Impact factor: 5.157

Review 5. Synthesis and processing of avian sarcoma retrovirus RNA.

Authors: C M Stoltzfus
Journal: Adv Virus Res Date: 1988 Impact factor: 9.937

6. Myristyl amino-terminal acylation of murine retrovirus proteins: an unusual post-translational proteins modification.

Authors: L E Henderson; H C Krutzsch; S Oroszlan
Journal: Proc Natl Acad Sci U S A Date: 1983-01 Impact factor: 11.205

7. Purification and chemical and immunological characterization of avian reticuloendotheliosis virus gag-gene-encoded structural proteins.

Authors: W P Tsai; T D Copeland; S Oroszlan
Journal: Virology Date: 1985-01-30 Impact factor: 3.616

8. An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins.

Authors: D Pellman; E A Garber; F R Cross; H Hanafusa
Journal: Nature Date: 1985 Mar 28-Apr 3 Impact factor: 49.962

6. A single amino-acid substitution in gag p19 protein (MA) of Rous sarcoma virus suppresses virus production from infected cells.

Authors: H Hara; A Kaji
Journal: Virus Genes Date: 1998 Impact factor: 2.332

10. Characterization of a small (25-kilodalton) derivative of the Rous sarcoma virus Gag protein competent for particle release.

Authors: R A Weldon; J W Wills
Journal: J Virol Date: 1993-09 Impact factor: 5.103

Myristylation of Rous sarcoma virus Gag protein does not prevent replication in avian cells.

1. Site-directed mutagenesis of the gag-myc gene of avian myelocytomatosis virus 29: biological activity and intracellular localization of structurally altered proteins.

2. Mechanism of transfection of chicken embryo fibroblasts by Rous sarcoma virus DNA.

3. Myristylation site in Pr65gag is essential for virus particle formation by Moloney murine leukemia virus.

4. Fatty acylation of cellular proteins. Temporal and subcellular differences between palmitate and myristate acylation.

Review 5. Synthesis and processing of avian sarcoma retrovirus RNA.

6. Myristyl amino-terminal acylation of murine retrovirus proteins: an unusual post-translational proteins modification.

7. Purification and chemical and immunological characterization of avian reticuloendotheliosis virus gag-gene-encoded structural proteins.

8. An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins.

9. Avian sarcoma virus gag precursor polypeptide is not processed in mammalian cells.

10. In vivo modification of retroviral gag gene-encoded polyproteins by myristic acid.

1. RNA dimerization defect in a Rous sarcoma virus matrix mutant.

2. Suppression of retroviral MA deletions by the amino-terminal membrane-binding domain of p60src.

3. Role of the avian retroviral protease in the activation of reverse transcriptase during virion assembly.

Review 4. The structural biology of HIV assembly.

5. A large region within the Rous sarcoma virus matrix protein is dispensable for budding and infectivity.

6. A single amino-acid substitution in gag p19 protein (MA) of Rous sarcoma virus suppresses virus production from infected cells.

7. Intracellular trafficking of the UL11 tegument protein of herpes simplex virus type 1.

8. The membrane-binding domain of the Rous sarcoma virus Gag protein.

9. Conditions for copackaging rous sarcoma virus and murine leukemia virus Gag proteins during retroviral budding.

10. Characterization of a small (25-kilodalton) derivative of the Rous sarcoma virus Gag protein competent for particle release.