Literature DB >> 21689931

Reproducible enrichment of extracellular heat shock proteins from blood serum using monomeric avidin.

Doina M Mihai1, Haiteng Deng, Akira Kawamura.   

Abstract

Extracellular heat shock proteins (eHsps) in blood circulation have been associated with various diseases, including cancer. However, the lack of methods to enrich eHsps from serum samples has hampered the characterization of eHsps. This Letter presents our serendipitous finding that the monomeric avidin resin can serve as an affinity resin to enrich eHsps from blood serum. Biochemical mechanism of this eHsp enrichment as well as implications in biomarker discovery is discussed.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21689931      PMCID： PMC3136036          DOI： 10.1016/j.bmcl.2011.05.111

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


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