| Literature DB >> 21689902 |
Nitin Anand1, Paulomi M Sudhir, Suresh Bada Math, K Thennarasu, Y C Janardhan Reddy.
Abstract
Evidence of efficacy of cognitive behavior therapy (CBT) in obsessive-compulsive disorder (OCD) non-responsive to multiple trials of serotonin reuptake inhibitors (SRI) is limited. We examined the efficacy of CBT in 31 adult patients with DSM-IV OCD who were non-responders to at least two SRI trials. They received 20-25 sessions of CBT over 3-month duration. The primary outcome measure was "response" to treatment [Clinical Global Impressions-Improvement score 1 or 2 and ≥35% reduction in Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) severity score]. Patients were assessed at baseline, post-treatment and at 3-, 6- and 12-month follow-up. Twenty-six (84%) patients completed treatment and number of responders at post-treatment, 3-, 6- and 12-month follow-up were 23 (74%), 20 (64%), 20 (64%) and 19 (61%) respectively. Quality of homework compliance and baseline Y-BOCS severity predicted remission (Y-BOCS<16) to CBT. CBT is useful in OCD non-responsive to multiple trials of SRI.Entities:
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Year: 2011 PMID： 21689902 DOI： 10.1016/j.janxdis.2011.05.007
Source DB: PubMed Journal: J Anxiety Disord ISSN： 0887-6185