PURPOSE: To evaluate the effectiveness and patient satisfaction with the use of oxybutynin at low doses for treating palmar hyperhidrosis in a large series of patients. METHODS: From January 2007 to June 2009, 180 consecutive patients with palmar hyperhidrosis were treated with oxybutynin. Data were collected from 139 patients (41 patients were lost to follow-up). During the first week, patients received 2.5 mg of oxybutynin once per day; from the 8th to the 42nd day, 2.5 mg twice per day; and from the 43rd day to the end of the 12th week, 5 mg, twice per day. All of the patients underwent three evaluations before and after the oxybutynin treatment (at 6 and 12 weeks), using a clinical questionnaire and a clinical protocol for quality of life (QOL). RESULTS: More than 80% of the patients experienced an improvement in palmar hyperhidrosis. Most of the patients showed improvements in their QOL (74.6%). The side effects were minor, with dry mouth being the most frequent (70.5%). CONCLUSION: The use of oxybutynin is an alternative as the first step in the treatment of palmar hyperhidrosis, given that it presents good results and improves QOL.
PURPOSE: To evaluate the effectiveness and patient satisfaction with the use of oxybutynin at low doses for treating palmar hyperhidrosis in a large series of patients. METHODS: From January 2007 to June 2009, 180 consecutive patients with palmar hyperhidrosis were treated with oxybutynin. Data were collected from 139 patients (41 patients were lost to follow-up). During the first week, patients received 2.5 mg of oxybutynin once per day; from the 8th to the 42nd day, 2.5 mg twice per day; and from the 43rd day to the end of the 12th week, 5 mg, twice per day. All of the patients underwent three evaluations before and after the oxybutynin treatment (at 6 and 12 weeks), using a clinical questionnaire and a clinical protocol for quality of life (QOL). RESULTS: More than 80% of the patients experienced an improvement in palmar hyperhidrosis. Most of the patients showed improvements in their QOL (74.6%). The side effects were minor, with dry mouth being the most frequent (70.5%). CONCLUSION: The use of oxybutynin is an alternative as the first step in the treatment of palmar hyperhidrosis, given that it presents good results and improves QOL.
Authors: Carlos Alberto Almeida de Araújo; Italo Medeiros Azevedo; Maria Angela Fernandes Ferreira; Hylas Paiva da Costa Ferreira; Jorge Lúcio Costa de Medeiros Dantas; Aldo Cunha Medeiros Journal: J Bras Pneumol Date: 2009-03 Impact factor: 2.624
Authors: Nelson Wolosker; Marcelo Passos Teivelis; Mariana Krutman; Taiz Pereira Dozono de Almeida Campbell; Paulo Kauffman; José Ribas de Campos; Pedro Puech-Leão Journal: An Bras Dermatol Date: 2014 Nov-Dec Impact factor: 1.896
Authors: Nelson Wolosker; Marcelo Passos Teivelis; Mariana Krutman; Rafael P de Paula; José R M de Campos; Paulo Kauffman; Pedro Puech-Leão Journal: Clin Auton Res Date: 2014-11-27 Impact factor: 4.435
Authors: Nelson Wolosker; Mariana Krutman; Marcelo Passos Teivelis; Rafael Pessanha de Paula; Paulo Kauffman; Jose Ribas Milanez de Campos; Pedro Puech-Leão Journal: Einstein (Sao Paulo) Date: 2014 Jan-Mar