Literature DB >> 21687034

Response of facial haemangioma to oral propranolol.

Mohamad Hassan Itani1, Hadi Fakih.   

Abstract

Haemangioma is the most common vascular tumour of childhood. Most cases require no therapeutic intervention, with spontaneous involution by 5-9 years of age. Some haemangiomas may become large in size impinging on vital structures such as eyes, mouth, nose or larynx, and require certain therapeutic interventions to prevent major morbidities. The usual treatments include oral/intralesional steroids, α interferon, cytotoxins, remobilisation, pulsed dye laser and cosmetic surgery resection; these treatments are not free of multiple complications and toxic side effects. This report describes the case of a 4-month-old female baby with progressively increasing haemangioma of the right upper eyelid impinging over the upper outer visual field. The haemangioma responded promptly to low-dose oral propranolol. A clinical response was noticed few days after the start of the treatment and was free of any major side effects.

Entities:  

Year:  2009        PMID: 21687034      PMCID: PMC3027513          DOI: 10.1136/bcr.01.2009.1476

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  3 in total

1.  Propranolol for severe hemangiomas of infancy.

Authors:  Christine Léauté-Labrèze; Eric Dumas de la Roque; Thomas Hubiche; Franck Boralevi; Jean-Benoît Thambo; Alain Taïeb
Journal:  N Engl J Med       Date:  2008-06-12       Impact factor: 91.245

2.  cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation.

Authors:  G D'Angelo; H Lee; R I Weiner
Journal:  J Cell Biochem       Date:  1997-12-01       Impact factor: 4.429

Review 3.  Management of cutaneous hemangiomas in pediatric patients.

Authors:  Maria Letizia Musumeci; Karina Schlecht; Rosario Perrotta; Robert A Schwartz; Giuseppe Micali
Journal:  Cutis       Date:  2008-04
  3 in total
  2 in total

1.  Use of propranolol in infantile haemangiomas: report of five cases and review of the literature.

Authors:  D Gidaris; M Economou; V Hatzidemetriou; N Gombakis; M Athanassiou-Metaxa
Journal:  Hippokratia       Date:  2011-01       Impact factor: 0.471

Review 2.  Initiation and use of propranolol for infantile hemangioma: report of a consensus conference.

Authors:  Beth A Drolet; Peter C Frommelt; Sarah L Chamlin; Anita Haggstrom; Nancy M Bauman; Yvonne E Chiu; Robert H Chun; Maria C Garzon; Kristen E Holland; Leonardo Liberman; Susan MacLellan-Tobert; Anthony J Mancini; Denise Metry; Katherine B Puttgen; Marcia Seefeldt; Robert Sidbury; Kendra M Ward; Francine Blei; Eulalia Baselga; Laura Cassidy; David H Darrow; Shawna Joachim; Eun-Kyung M Kwon; Kari Martin; Jonathan Perkins; Dawn H Siegel; Robert J Boucek; Ilona J Frieden
Journal:  Pediatrics       Date:  2012-12-24       Impact factor: 7.124

  2 in total

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