Literature DB >> 21687012

A case of acquired trichomegaly following treatment with erlotinib.

Fiona Jazayeri1, Raman Malhotra.   

Abstract

A woman on erlotinib treatment for lung cancer presented with a corneal ulcer from aberrant eyelash touch. She developed coarse, hyperpigmented and irregular eyelash and eyebrow growth a few months following treatment. She was treated successfully with epilation, eyelash trimming, lid hygiene and intensive topical lubrication. This is the first case report in the UK of trichomegaly with associated corneal ulceration. Erlotinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that has recently been approved for use as a chemotherapeutic agent by the National Institute for Health and Clinical Excellence. Ophthalmologists and oncologists should be aware of the adnexal and ocular surface changes that can occur, and that simple interventions may be used to manage them.

Entities:  

Year:  2009        PMID: 21687012      PMCID: PMC3028406          DOI: 10.1136/bcr.01.2009.1473

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  4 in total

1.  Epidermal growth factor receptor inhibition induces trichomegaly.

Authors:  Svein Dueland; Torill Sauer; Fridtjof Lund-Johansen; Bjørn Ostenstad; Kjell Magne Tveit
Journal:  Acta Oncol       Date:  2003       Impact factor: 4.089

2.  Trichomegaly of the eyelashes after treatment with erlotinib in non-small cell lung cancer.

Authors:  Judith Elizabeth Carser; Yvonne Jane Summers
Journal:  J Thorac Oncol       Date:  2006-11       Impact factor: 15.609

3.  Erlotinib-associated trichomegaly.

Authors:  Katherine Lane; Scott M Goldstein
Journal:  Ophthalmic Plast Reconstr Surg       Date:  2007 Jan-Feb       Impact factor: 1.746

4.  Acquired trichomegaly and symptomatic external ocular changes in patients receiving epidermal growth factor receptor inhibitors: case reports and a review of literature.

Authors:  Grace Zhang; Surendra Basti; Lee M Jampol
Journal:  Cornea       Date:  2007-08       Impact factor: 2.651

  4 in total

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