RHO GTPase in plants: Conservation and invention of regulators and effectors.

Plants possess a single subfamily of Rho GTPases, ROP, which does usual things as do Rho-family GTPases in animal and fungal systems, namely participating in the spatial control of cellular processes by signaling to the cytoskeleton and vesicular trafficking. As one would expect, ROPs are modulated by conserved regulators such as DHR2-type GEFs, RhoGAPs and Rho GDIs. What is surprising is that plants have invented new regulators such as PRONE-type GEFs (known as RopGEFs) and effectors such as RICs and ICRs/RIPs in the regulation of the cytoskeleton and vesicular trafficking. This review will discuss recent work on characterizing ROP regulators and effectors as well as addressing why and how a mixture of conserved and novel Rho signaling mechanisms is utilized to modulate fundamental cellular processes such as cytoskeletal dynamics/reorganization and vesicular trafficking.