Literature DB >> 21685885

Huntington's disease: flipping a switch on huntingtin.

Erin R Greiner, X William Yang.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21685885     DOI： 10.1038/nchembio.604

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


× No keyword cloud information.
  10 in total

1.  IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

Authors:  Leslie Michels Thompson; Charity T Aiken; Linda S Kaltenbach; Namita Agrawal; Katalin Illes; Ali Khoshnan; Marta Martinez-Vincente; Montserrat Arrasate; Jacqueline Gire O'Rourke; Hasan Khashwji; Tamas Lukacsovich; Ya-Zhen Zhu; Alice L Lau; Ashish Massey; Michael R Hayden; Scott O Zeitlin; Steven Finkbeiner; Kim N Green; Frank M LaFerla; Gillian Bates; Lan Huang; Paul H Patterson; Donald C Lo; Ana Maria Cuervo; J Lawrence Marsh; Joan S Steffan
Journal:  J Cell Biol       Date:  2009-12-21       Impact factor: 10.539

2.  Polyglutamine expansion of huntingtin impairs its nuclear export.

Authors:  Jonathan Cornett; Fengli Cao; Chuan-En Wang; Christopher A Ross; Gillian P Bates; Shi-Hua Li; Xiao-Jiang Li
Journal:  Nat Genet       Date:  2005-01-16       Impact factor: 38.330

3.  Kinase inhibitors modulate huntingtin cell localization and toxicity.

Authors:  Randy Singh Atwal; Carly R Desmond; Nicholas Caron; Tamara Maiuri; Jianrun Xia; Simonetta Sipione; Ray Truant
Journal:  Nat Chem Biol       Date:  2011-05-29       Impact factor: 15.040

4.  The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.

Authors:  Erica Rockabrand; Natalia Slepko; Antonello Pantalone; Vidya N Nukala; Aleksey Kazantsev; J Lawrence Marsh; Patrick G Sullivan; Joan S Steffan; Stefano L Sensi; Leslie Michels Thompson
Journal:  Hum Mol Genet       Date:  2006-11-29       Impact factor: 6.150

5.  Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation.

Authors:  Lauren S Havel; Chuan-En Wang; Brandy Wade; Brenda Huang; Shihua Li; Xiao-Jiang Li
Journal:  Hum Mol Genet       Date:  2011-01-18       Impact factor: 6.150

6.  Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.

Authors:  Randy Singh Atwal; Jianrun Xia; Deborah Pinchev; Jillian Taylor; Richard M Epand; Ray Truant
Journal:  Hum Mol Genet       Date:  2007-08-18       Impact factor: 6.150

7.  Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.

Authors:  Xiaofeng Gu; Erin R Greiner; Rakesh Mishra; Ravindra Kodali; Alex Osmand; Steven Finkbeiner; Joan S Steffan; Leslie Michels Thompson; Ronald Wetzel; X William Yang
Journal:  Neuron       Date:  2009-12-24       Impact factor: 17.173

8.  SUMO modification of Huntingtin and Huntington's disease pathology.

Authors:  Joan S Steffan; Namita Agrawal; Judit Pallos; Erica Rockabrand; Lloyd C Trotman; Natalia Slepko; Katalin Illes; Tamas Lukacsovich; Ya-Zhen Zhu; Elena Cattaneo; Pier Paolo Pandolfi; Leslie Michels Thompson; J Lawrence Marsh
Journal:  Science       Date:  2004-04-02       Impact factor: 47.728

9.  Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism.

Authors:  Ashwani K Thakur; Murali Jayaraman; Rakesh Mishra; Monika Thakur; Veronique M Chellgren; In-Ja L Byeon; Dalaver H Anjum; Ravindra Kodali; Trevor P Creamer; James F Conway; Angela M Gronenborn; Ronald Wetzel
Journal:  Nat Struct Mol Biol       Date:  2009-03-08       Impact factor: 15.369

10.  The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation.

Authors:  Stephen Tam; Christoph Spiess; William Auyeung; Lukasz Joachimiak; Bryan Chen; Michelle A Poirier; Judith Frydman
Journal:  Nat Struct Mol Biol       Date:  2009-11-15       Impact factor: 15.369
  10 in total
  9 in total

Review 1.  Polyglutamine misfolding in yeast: toxic and protective aggregation.

Authors:  Martin L Duennwald
Journal:  Prion       Date:  2011-10-01       Impact factor: 3.931

Review 2.  Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.

Authors:  C Y Daniel Lee; Jeffrey P Cantle; X William Yang
Journal:  FEBS J       Date:  2013-07-31       Impact factor: 5.542

3.  Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties.

Authors:  Nathan Riguet; Anne-Laure Mahul-Mellier; Niran Maharjan; Johannes Burtscher; Marie Croisier; Graham Knott; Janna Hastings; Alice Patin; Veronika Reiterer; Hesso Farhan; Sergey Nasarov; Hilal A Lashuel
Journal:  Nat Commun       Date:  2021-11-12       Impact factor: 14.919

4.  NMR spectroscopy, excited states and relevance to problems in cell biology - transient pre-nucleation tetramerization of huntingtin and insights into Huntington's disease.

Authors:  G Marius Clore
Journal:  J Cell Sci       Date:  2022-06-15       Impact factor: 5.235

5.  TRiC's tricks inhibit huntingtin aggregation.

Authors:  Sarah H Shahmoradian; Jesus G Galaz-Montoya; Michael F Schmid; Yao Cong; Boxue Ma; Christoph Spiess; Judith Frydman; Steven J Ludtke; Wah Chiu
Journal:  Elife       Date:  2013-07-09       Impact factor: 8.140

6.  Bifunctional anti-huntingtin proteasome-directed intrabodies mediate efficient degradation of mutant huntingtin exon 1 protein fragments.

Authors:  David C Butler; Anne Messer
Journal:  PLoS One       Date:  2011-12-22       Impact factor: 3.240

7.  Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.

Authors:  Erin E Watkin; Nicolas Arbez; Elaine Waldron-Roby; Robert O'Meally; Tamara Ratovitski; Robert N Cole; Christopher A Ross
Journal:  PLoS One       Date:  2014-02-05       Impact factor: 3.240

8.  Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.

Authors:  Lois S Weisman; Juan Botas; Ismael Al-Ramahi; Sai Srinivas Panapakkam Giridharan; Yu-Chi Chen; Samarjit Patnaik; Nathaniel Safren; Junya Hasegawa; Maria de Haro; Amanda K Wagner Gee; Steven A Titus; Hyunkyung Jeong; Jonathan Clarke; Dimitri Krainc; Wei Zheng; Robin F Irvine; Sami Barmada; Marc Ferrer; Noel Southall; Juan Jose Marugan
Journal:  Elife       Date:  2017-12-26       Impact factor: 8.140

Review 9.  Targeting the proteostasis network in Huntington's disease.

Authors:  Tânia R Soares; Sara D Reis; Brígida R Pinho; Michael R Duchen; Jorge M A Oliveira
Journal:  Ageing Res Rev       Date:  2018-11-28       Impact factor: 10.895
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.