PURPOSE: HIV infection has been implicated in dysregulation of the autonomic nervous system. METHOD: Cross-sectional study examining the relationship between the presence of persistent detectable HIV viral load with autonomic function, measured by heart rate variability (HRV). Non-virologic suppression (NVS) was defined as having a detectable viral load for at least 3 months prior to autonomic function testing. HRV was measured during the following 4 maneuvers: resting and paced respirations and sustained handgrip and tilt. Inferences on parasympathetic and sympathetic modulations were determined by analyzing time and frequency domains of HRV. RESULTS: 57 participants were enrolled in 3 groups: 22 were HIV-infected participants with HIV virologic suppression (VS; undetectable HIV viral load), 9 were HIV-infected participants who had NVS, and 26 were HIV seronegative controls. There were lower time domain parameters in the HIV-infected group as a whole compared to controls. There were no significant differences in time domain parameters among HIV-infected participants. There were no differences in frequency domain parameters during any of the maneuvers between controls and all HIV-infected participants, nor between the NVS and VS groups. CONCLUSION: There were differences in autonomic function between HIV-infected individuals and HIV seronegative controls, but not between the NVS and VS groups.
PURPOSE:HIV infection has been implicated in dysregulation of the autonomic nervous system. METHOD: Cross-sectional study examining the relationship between the presence of persistent detectable HIV viral load with autonomic function, measured by heart rate variability (HRV). Non-virologic suppression (NVS) was defined as having a detectable viral load for at least 3 months prior to autonomic function testing. HRV was measured during the following 4 maneuvers: resting and paced respirations and sustained handgrip and tilt. Inferences on parasympathetic and sympathetic modulations were determined by analyzing time and frequency domains of HRV. RESULTS: 57 participants were enrolled in 3 groups: 22 were HIV-infectedparticipants with HIV virologic suppression (VS; undetectable HIV viral load), 9 were HIV-infectedparticipants who had NVS, and 26 were HIV seronegative controls. There were lower time domain parameters in the HIV-infected group as a whole compared to controls. There were no significant differences in time domain parameters among HIV-infectedparticipants. There were no differences in frequency domain parameters during any of the maneuvers between controls and all HIV-infectedparticipants, nor between the NVS and VS groups. CONCLUSION: There were differences in autonomic function between HIV-infected individuals and HIV seronegative controls, but not between the NVS and VS groups.
Authors: D Liao; J Cai; W D Rosamond; R W Barnes; R G Hutchinson; E A Whitsel; P Rautaharju; G Heiss Journal: Am J Epidemiol Date: 1997-04-15 Impact factor: 4.897
Authors: Lari C Young; Mollie P Roediger; Greg Grandits; Jason Baker; Charurut Somboonwit; Ian Williams; Jens D Lundgren; James D Neaton; Elsayed Z Soliman Journal: Biomark Med Date: 2014 Impact factor: 2.851
Authors: Shia T Kent; Greer A Burkholder; Gabriel S Tajeu; E Turner Overton; Paul Muntner Journal: Curr Hypertens Rep Date: 2015-11 Impact factor: 5.369
Authors: Morgan H Kocher; Ronald K Hetzler; Cecilia M Shikuma; Iris F Kimura; Cris D Stickley; Rachel A Lindsey; Beau K Nakamoto; Dominic C Chow Journal: Jacobs J AIDS HIV Date: 2015-06
Authors: Manuel Delgado-Vélez; Carlos A Báez-Pagán; Yamil Gerena; Orestes Quesada; Laura I Santiago-Pérez; Coral M Capó-Vélez; Valerie Wojna; Loyda Meléndez; Rosiris León-Rivera; Walter Silva; José A Lasalde-Dominicci Journal: Clin Transl Immunology Date: 2015-12-11