Literature DB >> 21683628

Phospholipase C-β3 regulates FcɛRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1.

Wenbin Xiao1, Jun-Ichi Kashiwakura, Hong Hong, Hiroki Yasudo, Tomoaki Ando, Mari Maeda-Yamamoto, Dianqing Wu, Yuko Kawakami, Toshiaki Kawakami.   

Abstract

Mast cells are major effectors in high-affinity IgE receptor (FcɛRI)-dependent allergic reactions. Here we show that phospholipase C (PLC)-β3 is crucial for FcɛRI-mediated mast cell activation. Plcb3(-/-) mice showed blunted FcɛRI-dependent late-phase, but not acute, anaphylactic responses and airway inflammation. Accordingly, FcɛRI stimulation of Plcb3(-/-) mast cells exhibited reduced cytokine production but normal degranulation. Reduced cytokine production in Plcb3(-/-) cells could be accounted for by increased activity of the negative regulatory Src family kinase Lyn and reduced activities of the positive regulatory protein kinases MAPKs. Mechanistically, PLC-β3 constitutively interacts with FcɛRI, Lyn, and SHP-1 (protein phosphatase). SHP-1 probably recognizes its substrates Lyn and MAPKs via the recently described kinase tyrosine-based inhibitory motif, KTIM. Consistent with PLC-β3- and SHP-1-mediated repression of Lyn activity by dephosphorylation at Tyr396, FcɛRI-mediated phenotypes were similar in Plcb3(-/-) and SHP-1 mutant mast cells. Thus, we have defined a PLC-β3- and SHP-1-mediated signaling pathway for FcɛRI-mediated cytokine production.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21683628      PMCID： PMC3124618          DOI： 10.1016/j.immuni.2011.04.010

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  62 in total

1.  Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI.

Authors:  Jiro Kitaura; Jinming Song; Mindy Tsai; Koichi Asai; Mari Maeda-Yamamoto; Attila Mocsai; Yuko Kawakami; Fu-Tong Liu; Clifford A Lowell; B George Barisas; Stephen J Galli; Toshiaki Kawakami
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-20       Impact factor: 11.205

2.  Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.

Authors:  Valerie Hernandez-Hansen; Alexander J Smith; Zurab Surviladze; Alexandre Chigaev; Tomas Mazel; Janet Kalesnikoff; Clifford A Lowell; Gerald Krystal; Larry A Sklar; Bridget S Wilson; Janet M Oliver
Journal:  J Immunol       Date:  2004-07-01       Impact factor: 5.422

Review 3.  Signaling to NF-kappaB.

Authors:  Matthew S Hayden; Sankar Ghosh
Journal:  Genes Dev       Date:  2004-09-15       Impact factor: 11.361

4.  Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors.

Authors:  Robin W Freeburn; Karen L Wright; Steven J Burgess; Emmanuelle Astoul; Doreen A Cantrell; Stephen G Ward
Journal:  J Immunol       Date:  2002-11-15       Impact factor: 5.422

5.  Dok protein family members are involved in signaling mediated by the type 1 Fcepsilon receptor.

Authors:  Jakub Abramson; Guido Rozenblum; Israel Pecht
Journal:  Eur J Immunol       Date:  2003-01       Impact factor: 5.532

6.  A minor catalytic activity of Src family kinases is sufficient for maximal activation of mast cells via the high-affinity IgE receptor.

Authors:  Michael Poderycki; Yoshiaki Tomimori; Tomoaki Ando; Wenbin Xiao; Mari Maeda-Yamamoto; Karsten Sauer; Yuko Kawakami; Toshiaki Kawakami
Journal:  J Immunol       Date:  2009-11-30       Impact factor: 5.422

7.  Mast cells, Fc epsilon RI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant.

Authors:  Christian Taube; Xudong Wei; Christina H Swasey; Anthony Joetham; Simona Zarini; Tricia Lively; Katsuyuki Takeda; Joan Loader; Nobuaki Miyahara; Taku Kodama; Lenny D Shultz; Debra D Donaldson; Eckard H Hamelmann; Azzeddine Dakhama; Erwin W Gelfand
Journal:  J Immunol       Date:  2004-05-15       Impact factor: 5.422

8.  Positive and negative regulation of Fc epsilon receptor I-mediated signaling events by Lyn kinase C-terminal tyrosine phosphorylation.

Authors:  Pavel Tolar; Lubica Dráberová; Helena Tolarová; Petr Dráber
Journal:  Eur J Immunol       Date:  2004-04       Impact factor: 5.532

9.  Markers for detergent-resistant lipid rafts occupy distinct and dynamic domains in native membranes.

Authors:  Bridget S Wilson; Stanly L Steinberg; Karin Liederman; Janet R Pfeiffer; Zurab Surviladze; Jun Zhang; Lawrence E Samelson; Li-Hong Yang; Paul G Kotula; Janet M Oliver
Journal:  Mol Biol Cell       Date:  2004-03-19       Impact factor: 4.138

10.  Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase.

Authors:  Sandra Odom; Gregorio Gomez; Martina Kovarova; Yasuko Furumoto; John J Ryan; Harry V Wright; Claudia Gonzalez-Espinosa; Margaret L Hibbs; Kenneth W Harder; Juan Rivera
Journal:  J Exp Med       Date:  2004-06-01       Impact factor: 14.307
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  14 in total

Review 1.  Immune regulation by phospholipase C-β isoforms.

Authors:  Wenbin Xiao; Yuko Kawakami; Toshiaki Kawakami
Journal:  Immunol Res       Date:  2013-05       Impact factor: 2.829

Review 2.  Signal transduction and chemotaxis in mast cells.

Authors:  Petr Draber; Ivana Halova; Iva Polakovicova; Toshiaki Kawakami
Journal:  Eur J Pharmacol       Date:  2015-05-02       Impact factor: 4.432

3.  Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation.

Authors:  Jing Wang; Ikuo Shiratori; Junji Uehori; Masahito Ikawa; Hisashi Arase
Journal:  Nat Immunol       Date:  2012-11-11       Impact factor: 25.606

Review 4.  Phospholipase C-β in immune cells.

Authors:  Toshiaki Kawakami; Wenbin Xiao
Journal:  Adv Biol Regul       Date:  2013-08-14

5.  Fine-Tuning of Mast Cell Activation by FcεRIβ Chain.

Authors:  Chisei Ra; Satoshi Nunomura; Yoshimichi Okayama
Journal:  Front Immunol       Date:  2012-05-16       Impact factor: 7.561

6.  CDC42-Interacting Protein 4 Gene Is Down Trans-Regulated by HBV DNA polymerase Trans Activated Protein 1.

Authors:  Yongzhi Lun; Chongbo Xu; Qing Chi; Xuelei Wang; Wen Sui; Sujuan Jiang
Journal:  Iran J Public Health       Date:  2014-03       Impact factor: 1.429

7.  Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response.

Authors:  Di Wang; Mingzhu Zheng; Yuanjun Qiu; Chuansheng Guo; Jian Ji; Lei Lei; Xue Zhang; Jingjing Liang; Jun Lou; Wei Huang; Bowen Dong; Songquan Wu; Jianli Wang; Yuehai Ke; Xuetao Cao; Yi Ting Zhou; Linrong Lu
Journal:  J Exp Med       Date:  2014-11-24       Impact factor: 14.307

8.  Optimal aggregation of FcεRI with a structurally defined trivalent ligand overrides negative regulation driven by phosphatases.

Authors:  Avanika Mahajan; Dipak Barua; Patrick Cutler; Diane S Lidke; Flor A Espinoza; Carolyn Pehlke; Rachel Grattan; Yuko Kawakami; Chang-Shung Tung; Andrew R M Bradbury; William S Hlavacek; Bridget S Wilson
Journal:  ACS Chem Biol       Date:  2014-05-15       Impact factor: 5.100

9.  A Critical Role for Na+/H+ Exchanger Regulatory Factor 1 in Modulating FcεRI-Mediated Mast Cell Activation.

Authors:  Ananth K Kammala; Meesum Syed; Canchai Yang; Christopher J Occhiuto; Hariharan Subramanian
Journal:  J Immunol       Date:  2020-12-23       Impact factor: 5.422

10.  Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool.

Authors:  Yan-Feng Li; Shengli Xu; Xijun Ou; Kong-Peng Lam
Journal:  Nat Commun       Date:  2014-06-30       Impact factor: 14.919
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