Literature DB >> 2168319

Voltage sensitivity of NMDA-receptor mediated postsynaptic currents.

A Konnerth1, B U Keller, K Ballanyi, Y Yaari.   

Abstract

Patch-clamp techniques were used to record pharmacologically-isolated N-methyl-D-aspartate-mediated excitatory postsynaptic currents (NMDA-EPSCs) from dentate granule cells in thin rat hippocampal slices. Membrane voltage modulated these EPSCs in two ways. Firstly, depolarization from resting potential enhanced EPSC amplitudes, as expected for a voltage-dependent block by Mg2+ of synaptically activated NMDA receptor channels. Secondly, depolarization markedly prolonged the time course of decay of NMDA-EPSCs in normal and low extracellular Mg2+. Both mechanisms were complementary in establishing a strong dependence between membrane potential and the amount of charge, namely Ca2+, transferred through synaptically activated NMDA receptor channels, that presumably underlies induction of long-term potentiation in the hippocampus.

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Year:  1990        PMID： 2168319     DOI： 10.1007/BF00230117

Source DB:  PubMed          Journal:  Exp Brain Res        ISSN： 0014-4819            Impact factor:   1.972


  28 in total

1.  The effect of magnesium on the activity of motor nerve endings.

Authors:  J DEL CASTILLO; B KATZ
Journal:  J Physiol       Date:  1954-06-28       Impact factor: 5.182

2.  Slow excitatory postsynaptic currents mediated by N-methyl-D-aspartate receptors on cultured mouse central neurones.

Authors:  I D Forsythe; G L Westbrook
Journal:  J Physiol       Date:  1988-02       Impact factor: 5.182

3.  A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system.

Authors:  F A Edwards; A Konnerth; B Sakmann; T Takahashi
Journal:  Pflugers Arch       Date:  1989-09       Impact factor: 3.657

4.  Postsynaptic calcium is sufficient for potentiation of hippocampal synaptic transmission.

Authors:  R C Malenka; J A Kauer; R S Zucker; R A Nicoll
Journal:  Science       Date:  1988-10-07       Impact factor: 47.728

5.  Theta pattern stimulation and the induction of LTP: the sequence in which synapses are stimulated determines the degree to which they potentiate.

Authors:  J Larson; G Lynch
Journal:  Brain Res       Date:  1989-06-05       Impact factor: 3.252

6.  Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Authors:  O P Hamill; A Marty; E Neher; B Sakmann; F J Sigworth
Journal:  Pflugers Arch       Date:  1981-08       Impact factor: 3.657

7.  Activation of N-methyl-D-aspartate receptors contributes to the EPSP at perforant path synapses in the rat dentate gyrus in vitro.

Authors:  J D Lambert; R S Jones
Journal:  Neurosci Lett       Date:  1989-02-27       Impact factor: 3.046

8.  Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones.

Authors:  M L Mayer; G L Westbrook; P B Guthrie
Journal:  Nature       Date:  1984 May 17-23       Impact factor: 49.962

9.  Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain.

Authors:  R P Simon; J H Swan; T Griffiths; B S Meldrum
Journal:  Science       Date:  1984-11-16       Impact factor: 47.728

10.  CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rat hippocampal slices.

Authors:  J F Blake; M W Brown; G L Collingridge
Journal:  Neurosci Lett       Date:  1988-06-29       Impact factor: 3.046
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  22 in total

1.  Postsynaptic variability of firing in rat cortical neurons: the roles of input synchronization and synaptic NMDA receptor conductance.

Authors:  A Harsch; H P Robinson
Journal:  J Neurosci       Date:  2000-08-15       Impact factor: 6.167

2.  A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons.

Authors:  F Pongrácz; N P Poolos; J D Kocsis; G M Shepherd
Journal:  J Neurophysiol       Date:  1992-12       Impact factor: 2.714

3.  Fast and slow voltage-dependent dynamics of magnesium block in the NMDA receptor: the asymmetric trapping block model.

Authors:  Mariana Vargas-Caballero; Hugh P C Robinson
Journal:  J Neurosci       Date:  2004-07-07       Impact factor: 6.167

4.  Voltage-dependent gating of NR1/2B NMDA receptors.

Authors:  Richard J Clarke; Jon W Johnson
Journal:  J Physiol       Date:  2008-10-20       Impact factor: 5.182

5.  Synaptic NMDA receptors in developing mouse hippocampal neurones: functional properties and sensitivity to ifenprodil.

Authors:  E D Kirson; Y Yaari
Journal:  J Physiol       Date:  1996-12-01       Impact factor: 5.182

6.  Synaptic- and agonist-induced excitatory currents of Purkinje cells in rat cerebellar slices.

Authors:  I Llano; A Marty; C M Armstrong; A Konnerth
Journal:  J Physiol       Date:  1991-03       Impact factor: 5.182

7.  Mechanistic and structural determinants of NMDA receptor voltage-dependent gating and slow Mg2+ unblock.

Authors:  Richard J Clarke; Nathan G Glasgow; Jon W Johnson
Journal:  J Neurosci       Date:  2013-02-27       Impact factor: 6.167

8.  Evidence that heterosynaptic depolarization underlies associativity of long-term potentiation in rat hippocampus.

Authors:  K A Clark; G L Collingridge
Journal:  J Physiol       Date:  1996-01-15       Impact factor: 5.182

9.  Characterization of Ca2+ signals induced in hippocampal CA1 neurones by the synaptic activation of NMDA receptors.

Authors:  S Alford; B G Frenguelli; J G Schofield; G L Collingridge
Journal:  J Physiol       Date:  1993-09       Impact factor: 5.182

10.  Synaptic NR2A- but not NR2B-Containing NMDA Receptors Increase with Blockade of Ionotropic Glutamate Receptors.

Authors:  Jakob von Engelhardt; Beril Doganci; Peter H Seeburg; Hannah Monyer
Journal:  Front Mol Neurosci       Date:  2009-10-26       Impact factor: 5.639
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