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Literature DB >> 21683139

Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle.

Tim T Chiu¹, Thomas E Jensen, Lykke Sylow, Erik A Richter, Amira Klip.

Abstract

Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.

Entities: Chemical Gene

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Year: 2011 PMID： 21683139 DOI： 10.1016/j.cellsig.2011.05.022

Source DB: PubMed Journal: Cell Signal ISSN： 0898-6568 Impact factor: 4.315

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Cited

61 in total

Review 1. GLUT4 exocytosis.

Authors: Jacqueline Stöckli; Daniel J Fazakerley; David E James
Journal: J Cell Sci Date: 2011-12-15 Impact factor: 5.285

2. Identification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes.

Authors: Demis Balamatsias; Anne M Kong; Joanne E Waters; Absorn Sriratana; Rajendra Gurung; Charles G Bailey; John E J Rasko; Tony Tiganis; S Lance Macaulay; Christina A Mitchell
Journal: J Biol Chem Date: 2011-10-15 Impact factor: 5.157

3. Rac1: an emerging player in stretch-stimulated glucose transport.

Authors: Pratiek N Matkar; Wei J Cao; Hao H Chen; Robert Civitarese; Ruta Jog; Antoinette Bugyei-Twum
Journal: J Physiol Date: 2015-04-15 Impact factor: 5.182

4. Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.

Authors: Lam O Huang; Alexander Rauch; Eugenia Mazzaferro; Michael Preuss; Stefania Carobbio; Cigdem S Bayrak; Nathalie Chami; Zhe Wang; Ursula M Schick; Nancy Yang; Yuval Itan; Antonio Vidal-Puig; Marcel den Hoed; Susanne Mandrup; Tuomas O Kilpeläinen; Ruth J F Loos
Journal: Nat Metab Date: 2021-02-22

Review 5. A molecular rheostat at the interface of cancer and diabetes.

Authors: Mahasin A Osman; Fazlul H Sarkar; Enrique Rodriguez-Boulan
Journal: Biochim Biophys Acta Date: 2013-04-29

Review 6. Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise.

Authors: Gregory D Cartee
Journal: Am J Physiol Endocrinol Metab Date: 2015-10-20 Impact factor: 4.310

Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle.

Review 1. GLUT4 exocytosis.

2. Identification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes.

3. Rac1: an emerging player in stretch-stimulated glucose transport.

4. Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.

Review 5. A molecular rheostat at the interface of cancer and diabetes.

Review 6. Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise.

Review 7. A proteolytic pathway that controls glucose uptake in fat and muscle.

Review 8. Mechanisms of Insulin Action and Insulin Resistance.

9. Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice.

Review 10. Regulation of NADPH oxidases in skeletal muscle.