OBJECTIVES: We compared nitrite, B-type natriuretic peptide (BNP), and cGMP levels in preeclamptic with those found in healthy pregnant. METHODS: We studied 21 healthy pregnant and 27 preeclamptic. Plasma cGMP and BNP levels were determined by ELISA. Nitrite levels were determined by chemiluminescence. RESULTS: Higher cGMP and BNP, and lower nitrite levels were found in preeclamptic versus healthy pregnant. CONCLUSIONS: Altered cGMP levels reflect increased BNP levels and not impaired nitric oxide activity in preeclampsia.
OBJECTIVES: We compared nitrite, B-type natriuretic peptide (BNP), and cGMP levels in preeclamptic with those found in healthy pregnant. METHODS: We studied 21 healthy pregnant and 27 preeclamptic. Plasma cGMP and BNP levels were determined by ELISA. Nitrite levels were determined by chemiluminescence. RESULTS: Higher cGMP and BNP, and lower nitrite levels were found in preeclamptic versus healthy pregnant. CONCLUSIONS: Altered cGMP levels reflect increased BNP levels and not impaired nitric oxide activity in preeclampsia.
Authors: Ana C Palei; Hunter L Martin; Barbara A Wilson; Christopher D Anderson; Joey P Granger; Frank T Spradley Journal: Am J Physiol Heart Circ Physiol Date: 2021-03-12 Impact factor: 4.733
Authors: Lorena M Amaral; Valeria C Sandrim; Matthew E Kutcher; Frank T Spradley; Ricardo C Cavalli; Jose E Tanus-Santos; Ana C Palei Journal: Int J Mol Sci Date: 2021-01-08 Impact factor: 6.208