Literature DB >> 21681431

Expression of Nogo-66 receptor in human astrocytoma is correlated with tumor malignancy.

Nanxiang Xiong1, Jianying Shen, Shuai Li, Junjun Li, Hongyang Zhao.   

Abstract

Nogo-A is a myelin-associated neuronal growth inhibitory molecule in central nervous system after trauma. However, the physiological functions of Nogo-A in neural development and in healthy oligodendrocytes are largely unknown. In this study, we investigated the expression of Nogo-66 receptor (NgR) protein in 60 cases of human astrocytoma by Western blot RT-PCR and immunohistochemistry. The correlation between the expression of NgR and pathologic grades of astrocyoma was further analyzed. The results showed that the expression of NgR protein and NgR mRNA immunoreactivity score, were decreased markedly with the increasing pathological grades. Double immunostaining results showed that Nogo-A and NgR were colocalized at the interface of astrocytoma cells and extracellular matrix. Our results indicated that NgR may have inhibitory effects on tumor activity and Nogo-A may restrict migration of tumor cells via NgR.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21681431     DOI： 10.1007/s11033-011-1015-8

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  22 in total

1.  Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions.

Authors:  Thomas Oertle; Marjan E van der Haar; Christine E Bandtlow; Anna Robeva; Patricia Burfeind; Armin Buss; Andrea B Huber; Marjo Simonen; Lisa Schnell; Christian Brösamle; Klemens Kaupmann; Rüdiger Vallon; Martin E Schwab
Journal:  J Neurosci       Date:  2003-07-02       Impact factor: 6.167

2.  LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.

Authors:  Sha Mi; Xinhua Lee; Zhaohui Shao; Greg Thill; Benxiu Ji; Jane Relton; Melissa Levesque; Norm Allaire; Steve Perrin; Bryan Sands; Thomas Crowell; Richard L Cate; John M McCoy; R Blake Pepinsky
Journal:  Nat Neurosci       Date:  2004-02-15       Impact factor: 24.884

Review 3.  Biological mechanisms of glioma invasion and potential therapeutic targets.

Authors:  B B Tysnes; R Mahesparan
Journal:  J Neurooncol       Date:  2001-06       Impact factor: 4.130

4.  Soluble Nogo-A, an inhibitor of axonal regeneration, as a biomarker for multiple sclerosis.

Authors:  Anna Jurewicz; Mariola Matysiak; Cedric S Raine; Krzysztof Selmaj
Journal:  Neurology       Date:  2007-01-23       Impact factor: 9.910

5.  A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein.

Authors:  Scott T Wong; John R Henley; Kevin C Kanning; Kuo-hua Huang; Mark Bothwell; Mu-ming Poo
Journal:  Nat Neurosci       Date:  2002-12       Impact factor: 24.884

6.  P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.

Authors:  Kevin C Wang; Jieun A Kim; Rajeev Sivasankaran; Rosalind Segal; Zhigang He
Journal:  Nature       Date:  2002-10-20       Impact factor: 49.962

7.  Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1.

Authors:  M S Chen; A B Huber; M E van der Haar; M Frank; L Schnell; A A Spillmann; F Christ; M E Schwab
Journal:  Nature       Date:  2000-01-27       Impact factor: 49.962

8.  Spreading and migration of human glioma and rat C6 cells on central nervous system myelin in vitro is correlated with tumor malignancy and involves a metalloproteolytic activity.

Authors:  V R Amberger; T Hensel; N Ogata; M E Schwab
Journal:  Cancer Res       Date:  1998-01-01       Impact factor: 12.701

9.  The synthetic cannabinoid R(+)WIN 55,212-2 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid receptor-independent manner.

Authors:  Niamh M Curran; Bryan D Griffin; Daniel O'Toole; Kevin J Brady; Stephen N Fitzgerald; Paul N Moynagh
Journal:  J Biol Chem       Date:  2005-08-16       Impact factor: 5.157

10.  The N-terminal domain of Nogo-A inhibits cell adhesion and axonal outgrowth by an integrin-specific mechanism.

Authors:  Fenghua Hu; Stephen M Strittmatter
Journal:  J Neurosci       Date:  2008-01-30       Impact factor: 6.167
View more
  2 in total

1.  Distinct roles of Nogo-a and Nogo receptor 1 in the homeostatic regulation of adult neural stem cell function and neuroblast migration.

Authors:  Chiara Rolando; Roberta Parolisi; Enrica Boda; Martin E Schwab; Ferdinando Rossi; Annalisa Buffo
Journal:  J Neurosci       Date:  2012-12-05       Impact factor: 6.167

2.  A Nogo-Like Signaling Perspective from Birth to Adulthood and in Old Age: Brain Expression Patterns of Ligands, Receptors and Modulators.

Authors:  Gabriella Smedfors; Lars Olson; Tobias E Karlsson
Journal:  Front Mol Neurosci       Date:  2018-02-19       Impact factor: 5.639
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.