BACKGROUND: Regulatory T-cells (T-reg) play a central role in the immunopathogenesis of psoriasis. T-reg cells are both functionally and numerically impaired in psoriasis and they are up-regulated by drug therapy. OBJECTIVE: To analyse the circulating CD4+CD25 bright FOXP3+ subset in 14 patients with vulgaris/arthropathic psoriasis treated with biological drugs and to investigate their relationship with the clinical response. METHODS: The CD4+ CD25 bright FOXP3+ expression was determined in peripheral blood by flow cytometry at baseline and during treatment. RESULTS: A response was obtained in 10/14 patients with increased CD4+ CD25 bright FOXP3+ (T-reg) in peripheral blood after the first month and then 4 months after therapy with biological drugs. This increase is associated with the achievement of a clinical response and with a reduction in the Psoriasis Activity and Severity Index (PASI) score. 2/14 patients showed a decrease in T-reg after drug therapy and this decrease correlated with a worsening of the clinical skin. CONCLUSION: Biological drugs induce circulating T-reg up-regulation in psoriatic patients; such an increase is an early predictive marker of clinical response.
BACKGROUND: Regulatory T-cells (T-reg) play a central role in the immunopathogenesis of psoriasis. T-reg cells are both functionally and numerically impaired in psoriasis and they are up-regulated by drug therapy. OBJECTIVE: To analyse the circulating CD4+CD25 bright FOXP3+ subset in 14 patients with vulgaris/arthropathic psoriasis treated with biological drugs and to investigate their relationship with the clinical response. METHODS: The CD4+ CD25 bright FOXP3+ expression was determined in peripheral blood by flow cytometry at baseline and during treatment. RESULTS: A response was obtained in 10/14 patients with increased CD4+ CD25 bright FOXP3+ (T-reg) in peripheral blood after the first month and then 4 months after therapy with biological drugs. This increase is associated with the achievement of a clinical response and with a reduction in the Psoriasis Activity and Severity Index (PASI) score. 2/14 patients showed a decrease in T-reg after drug therapy and this decrease correlated with a worsening of the clinical skin. CONCLUSION: Biological drugs induce circulating T-reg up-regulation in psoriatic patients; such an increase is an early predictive marker of clinical response.
Authors: C Liu; H Liu; C Lu; J Deng; Y Yan; H Chen; Y Wang; C-L Liang; J Wei; L Han; Z Dai Journal: Clin Exp Immunol Date: 2019-08-26 Impact factor: 4.330
Authors: P Cordiali-Fei; L Bianchi; C Bonifati; E Trento; M Ruzzetti; F Francesconi; S Bultrini; G D'Agosto; V Bordignon; V Francavilla; A Tripiciano; A Chiricozzi; E Campione; C Cavallotti; A Orlandi; E Berardesca; A Di Carlo; S Chimenti; F Ensoli Journal: Mediators Inflamm Date: 2014-07-20 Impact factor: 4.711
Authors: Sandro C Furiati; Jonatas S Catarino; Marcos V Silva; Rafaela F Silva; Rayane B Estevam; Reginaldo B Teodoro; Sanivia L Pereira; Meire Ataide; Virmondes Rodrigues; Denise B R Rodrigues Journal: Sci Rep Date: 2019-05-17 Impact factor: 4.379
Authors: Pablo Chicharro; Pedro Rodríguez-Jiménez; Mar Llamas-Velasco; Nuria Montes; Ancor Sanz-García; Danay Cibrian; Alicia Vara; Manuel J Gómez; María Jiménez-Fernández; Pedro Martínez-Fleta; Inés Sánchez-García; Marta Lozano-Prieto; Juan C Triviño; Rebeca Miñambres; Francisco Sánchez-Madrid; Hortensia de la Fuente; Esteban Dauden Journal: Cells Date: 2020-07-02 Impact factor: 6.600