Literature DB >> 21678912

Important role of oxidative stress biomarkers in Huntington's disease.

Isaac Túnez1, Fernando Sánchez-López, Eduardo Agüera, Ricardo Fernández-Bolaños, Francisco Manuel Sánchez, Inmaculada Tasset-Cuevas.   

Abstract

This study examined global oxidative stress (GOS) and antioxidant system and their correlation with disease stage in 19 patients with HD. The results revealed an increase in oxidative stress biomarkers and a reduction in antioxidant systems in HD patients. The effects were more intense in HD1 than in HD2 patients. Additionally, carbonylated proteins and GOS were correlated with disease stage. These findings suggest that oxidative stress plays an important role in the pathogenesis of HD.

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Year:  2011        PMID： 21678912     DOI： 10.1021/jm200605a

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  22 in total

1.  Sodium selenite protects from 3-nitropropionic acid-induced oxidative stress in cultured primary cortical neurons.

Authors:  Dirleise Colle; Danúbia Bonfanti Santos; Viviane de Souza; Mark William Lopes; Rodrigo Bainy Leal; Patricia de Souza Brocardo; Marcelo Farina
Journal:  Mol Biol Rep       Date:  2018-12-03       Impact factor: 2.316

Review 2.  Antioxidants in Huntington's disease.

Authors:  Ashu Johri; M Flint Beal
Journal:  Biochim Biophys Acta       Date:  2011-11-23

Review 3.  Oxidation as an important factor of protein damage: Implications for Maillard reaction.

Authors:  L Trnkova; J Drsata; I Bousova
Journal:  J Biosci       Date:  2015-06       Impact factor: 1.826

4.  Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?

Authors:  Huanlian Chen; Travis T Denton; Hui Xu; Noel Calingasan; M Flint Beal; Gary E Gibson
Journal:  J Neurochem       Date:  2016-12       Impact factor: 5.372

Review 5.  Mitochondrial Abnormalities and Synaptic Damage in Huntington's Disease: a Focus on Defective Mitophagy and Mitochondria-Targeted Therapeutics.

Authors:  Neha Sawant; Hallie Morton; Sudhir Kshirsagar; Arubala P Reddy; P Hemachandra Reddy
Journal:  Mol Neurobiol       Date:  2021-09-14       Impact factor: 5.590

6.  Influence of intensive multifunctional neurorehabilitation on neuronal oxidative damage in patients with Huntington's disease.

Authors:  Irene Ciancarelli; Daniela De Amicis; Caterina Di Massimo; Giorgio Sandrini; Caterina Pistarini; Antonio Carolei; Maria Giuliana Tozzi Ciancarelli
Journal:  Funct Neurol       Date:  2015 Jan-Mar

Review 7.  PGC-1α, mitochondrial dysfunction, and Huntington's disease.

Authors:  Ashu Johri; Abhishek Chandra; M Flint Beal
Journal:  Free Radic Biol Med       Date:  2013-04-19       Impact factor: 7.376

8.  Role of N-terminal methionine residues in the redox activity of copper bound to alpha-synuclein.

Authors:  Esaú E Rodríguez; Trinidad Arcos-López; Lidia G Trujano-Ortiz; Claudio O Fernández; Felipe J González; Alberto Vela; Liliana Quintanar
Journal:  J Biol Inorg Chem       Date:  2016-07-15       Impact factor: 3.358

Review 9.  What, When and How to Measure-Peripheral Biomarkers in Therapy of Huntington's Disease.

Authors:  Lukasz Przybyl; Magdalena Wozna-Wysocka; Emilia Kozlowska; Agnieszka Fiszer
Journal:  Int J Mol Sci       Date:  2021-02-04       Impact factor: 5.923

10.  Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes.

Authors: 
Journal:  Cell Stem Cell       Date:  2012-06-28       Impact factor: 24.633
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