Literature DB >> 21677986

A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells.

Jiří Paleček1, Robert Zweigerdt, Ruth Olmer, Ulrich Martin, Andreas Kirschning, Gerald Dräger.   

Abstract

A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps and with a good overall yield of 45% starting from commercially available (R)-1-phenylethylamine. Compared to Y-27632 the new fluoro derivatives showed reduced or no effect on hPSC vitality and expansion after dissociation in human pluripotent stem cells.

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Year:  2011        PMID： 21677986     DOI： 10.1039/c1ob05332a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  12 in total

1.  Suspension culture of human pluripotent stem cells in controlled, stirred bioreactors.

Authors:  Ruth Olmer; Andreas Lange; Sebastian Selzer; Cornelia Kasper; Axel Haverich; Ulrich Martin; Robert Zweigerdt
Journal:  Tissue Eng Part C Methods       Date:  2012-06-04       Impact factor: 3.056

2.  Directing cardiomyogenic differentiation of human pluripotent stem cells by plasmid-based transient overexpression of cardiac transcription factors.

Authors:  Susann Hartung; Kristin Schwanke; Alexandra Haase; Robert David; Wolfgang-Michael Franz; Ulrich Martin; Robert Zweigerdt
Journal:  Stem Cells Dev       Date:  2013-01-18       Impact factor: 3.272

3.  Fast and efficient multitransgenic modification of human pluripotent stem cells.

Authors:  Kristin Schwanke; Sylvia Merkert; Henning Kempf; Susann Hartung; Monica Jara-Avaca; Christian Templin; Gudrun Göhring; Axel Haverich; Ulrich Martin; Robert Zweigerdt
Journal:  Hum Gene Ther Methods       Date:  2014-03-21       Impact factor: 2.396

4.  Impact of Feeding Strategies on the Scalable Expansion of Human Pluripotent Stem Cells in Single-Use Stirred Tank Bioreactors.

Authors:  Christina Kropp; Henning Kempf; Caroline Halloin; Diana Robles-Diaz; Annika Franke; Thomas Scheper; Katharina Kinast; Thomas Knorpp; Thomas O Joos; Axel Haverich; Ulrich Martin; Robert Zweigerdt; Ruth Olmer
Journal:  Stem Cells Transl Med       Date:  2016-07-01       Impact factor: 6.940

5.  Induction of pluripotent stem cells from a cynomolgus monkey using a polycistronic simian immunodeficiency virus-based vector, differentiation toward functional cardiomyocytes, and generation of stably expressing reporter lines.

Authors:  Stephanie Wunderlich; Alexandra Haase; Sylvia Merkert; Jennifer Beier; Kristin Schwanke; Axel Schambach; Silke Glage; Gudrun Göhring; Eliza C Curnow; Ulrich Martin
Journal:  Cell Reprogram       Date:  2012-12       Impact factor: 1.987

6.  Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells.

Authors:  Henning Kempf; Ruth Olmer; Alexandra Haase; Annika Franke; Emiliano Bolesani; Kristin Schwanke; Diana Robles-Diaz; Michelle Coffee; Gudrun Göhring; Gerald Dräger; Oliver Pötz; Thomas Joos; Erik Martinez-Hackert; Axel Haverich; Falk F R Buettner; Ulrich Martin; Robert Zweigerdt
Journal:  Nat Commun       Date:  2016-12-09       Impact factor: 14.919

7.  Sensitivity of human pluripotent stem cells to insulin precipitation induced by peristaltic pump-based medium circulation: considerations on process development.

Authors:  Diana Massai; Emiliano Bolesani; Diana Robles Diaz; Christina Kropp; Henning Kempf; Caroline Halloin; Ulrich Martin; Tudor Braniste; Giuseppe Isu; Vanessa Harms; Umberto Morbiducci; Gerald Dräger; Robert Zweigerdt
Journal:  Sci Rep       Date:  2017-06-21       Impact factor: 4.379

8.  EBIO Does Not Induce Cardiomyogenesis in Human Pluripotent Stem Cells but Modulates Cardiac Subtype Enrichment by Lineage-Selective Survival.

Authors:  Monica Jara-Avaca; Henning Kempf; Michael Rückert; Diana Robles-Diaz; Annika Franke; Jeanne de la Roche; Martin Fischer; Daniela Malan; Philipp Sasse; Wladimir Solodenko; Gerald Dräger; Andreas Kirschning; Ulrich Martin; Robert Zweigerdt
Journal:  Stem Cell Reports       Date:  2017-01-12       Impact factor: 7.765

9.  Continuous WNT Control Enables Advanced hPSC Cardiac Processing and Prognostic Surface Marker Identification in Chemically Defined Suspension Culture.

Authors:  Caroline Halloin; Kristin Schwanke; Wiebke Löbel; Annika Franke; Monika Szepes; Santoshi Biswanath; Stephanie Wunderlich; Sylvia Merkert; Natalie Weber; Felix Osten; Jeanne de la Roche; Felix Polten; Kai Christoph Wollert; Theresia Kraft; Martin Fischer; Ulrich Martin; Ina Gruh; Henning Kempf; Robert Zweigerdt
Journal:  Stem Cell Reports       Date:  2019-07-25       Impact factor: 7.765

10.  High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling.

Authors:  Felix Manstein; Kevin Ullmann; Christina Kropp; Caroline Halloin; Wiebke Triebert; Annika Franke; Clara-Milena Farr; Anais Sahabian; Alexandra Haase; Yannik Breitkreuz; Michael Peitz; Oliver Brüstle; Stefan Kalies; Ulrich Martin; Ruth Olmer; Robert Zweigerdt
Journal:  Stem Cells Transl Med       Date:  2021-03-04       Impact factor: 6.940
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