Literature DB >> 21677407

Genetic polymorphism of serotonin transporter 5-HTTLPR: involvement in smoking behaviour.

Maria Angelica Ehara Watanabe1, Sandra Odebrecht Vargas Nunes, Sandra Odebrechet Vargas Nunes, Marla Karine Amarante, Roberta Losi Guembarovski, Julie Massayo Maeda Oda, Kalil William Alves De Lima, Maria Helena Pelegrinelli Fungaro.   

Abstract

Data suggest that the serotonin (5-hydroxytryptamine, 5-HT) system is implicated in the pathogenesis of multiple neuropsychiatric disorders and may also be involved in smoking behaviour since nicotine increases brain serotonin secretion. It is known that smoking behaviour is influenced by both genetic and environmental factors. The present review examines the role of the serotonin transporter gene (5-HTT) in smoking behaviour and investigating studies that showed association of 5-HTT gene with smoking. This study discusses a polymorphism which has been investigated by many researchers, as the bi-allelic insertion/deletion polymorphism in the 5'- flanking promoter region (5-HTTLPR). This gene has received considerable attention in attempts to understand the molecular determinants of smoking. Therefore, in the present study, the relationship between genetic polymorphism of serotonin transporter in smoking behaviour is reviewed considering the interactive effect of genetic factors.

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Year:  2011        PMID： 21677407     DOI： 10.1007/s12041-011-0037-2

Source DB:  PubMed          Journal:  J Genet        ISSN： 0022-1333            Impact factor:   1.166


  69 in total

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Authors:  P J Fletcher; K M Korth; J W Chambers
Journal:  Psychopharmacology (Berl)       Date:  1999-12       Impact factor: 4.530

2.  Chipping away at the genetics of smoking behavior.

Authors:  Christopher I Amos; Margaret R Spitz; Paul Cinciripini
Journal:  Nat Genet       Date:  2010-05       Impact factor: 38.330

Review 3.  Pharmacogenetics and the serotonin system: initial studies and future directions.

Authors:  J Veenstra-VanderWeele; G M Anderson; E H Cook
Journal:  Eur J Pharmacol       Date:  2000-12-27       Impact factor: 4.432

4.  Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects.

Authors:  J Gelernter; H Kranzler; J F Cubells
Journal:  Hum Genet       Date:  1997-12       Impact factor: 4.132

5.  The role of the serotonin transporter gene in cigarette smoking.

Authors:  C Lerman; P G Shields; J Audrain; D Main; B Cobb; N R Boyd; N Caporaso
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  1998-03       Impact factor: 4.254

6.  Lack of association of the serotonin transporter gene promoter region polymorphism, 5-HTTLPR, including rs25531 with cigarette smoking and alcohol consumption.

Authors:  Henrik Rasmussen; Yu Bagger; Laszlo B Tanko; Claus Christiansen; Thomas Werge
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2009-06-05       Impact factor: 3.568

7.  A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans.

Authors:  Sean P David; Naga Venkatesha Murthy; Eugenii A Rabiner; Marcus R Munafó; Elaine C Johnstone; Robyn Jacob; Robert T Walton; Paul M Grasby
Journal:  J Neurosci       Date:  2005-03-09       Impact factor: 6.167

8.  Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.

Authors:  Avshalom Caspi; Karen Sugden; Terrie E Moffitt; Alan Taylor; Ian W Craig; HonaLee Harrington; Joseph McClay; Jonathan Mill; Judy Martin; Antony Braithwaite; Richie Poulton
Journal:  Science       Date:  2003-07-18       Impact factor: 47.728

9.  Serotonin transporter genotype and depressive symptoms moderate effects of nicotine on spatial working memory.

Authors:  Joshua M Carlson; David G Gilbert; Hege Riise; Norka E Rabinovich; Chihiro Sugai; Brett Froeliger
Journal:  Exp Clin Psychopharmacol       Date:  2009-06       Impact factor: 3.157

10.  Impulsive aggression in personality disorder correlates with tritiated paroxetine binding in the platelet.

Authors:  E F Coccaro; R J Kavoussi; Y I Sheline; J D Lish; J G Csernansky
Journal:  Arch Gen Psychiatry       Date:  1996-06
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  7 in total

1.  Association between smoking, nicotine dependence, and BDNF Val66Met polymorphism with BDNF concentrations in serum.

Authors:  Mumtaz Jamal; Willem Van der Does; Bernet M Elzinga; Marc L Molendijk; Brenda W J H Penninx
Journal:  Nicotine Tob Res       Date:  2014-09-02       Impact factor: 4.244

2.  Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals.

Authors:  Kalil William Alves de Lima; Roberta Losi Guembarovski; Julie Massayo Maeda Oda; Gyl Ramos; Benedito Valdecir Oliveira; Iglenir João Cavalli; Enilze Maria de Souza Fonseca Ribeiro; Marlene Silva Bardi Gonçalves; Mateus Nobrega Aoki; Sandra Odebrecht Vargas Nunes; Maria Angelica Ehara Watanabe
Journal:  Clin Exp Med       Date:  2011-05-31       Impact factor: 3.984

3.  Chronic social defeat up-regulates expression of the serotonin transporter in rat dorsal raphe nucleus and projection regions in a glucocorticoid-dependent manner.

Authors:  Jia Zhang; Yan Fan; Ying Li; Hobart Zhu; Liang Wang; Meng-Yang Zhu
Journal:  J Neurochem       Date:  2012-11-07       Impact factor: 5.372

4.  Genetic Polymorphism in the Promoter Region of Serotonin Transporter: Implications for Ethanol Abuse in Children and Adolescents.

Authors:  Carlos Eduardo Coral de Oliveira; Julie Massayo Maeda Oda; Carolina Batista Ariza; Roberta Losi Guembarovski; Bruna Karina Banin Hirata; Felipe Campos de Almeida; Nayara Delgado André; Maria Helena Pelegrinelli Fungaro; Maria Angelica Ehara Watanabe
Journal:  J Can Acad Child Adolesc Psychiatry       Date:  2016-02-01

5.  Evaluation of the promoter region polymorphism (5-HTTLPR) in the serotonin transporter gene in females with postpartum depression.

Authors:  Xiaoli Zhang; Lin Wang; Fenghua Huang; Jiafu Li; Li Xiong; Han Xue; Yuanzhen Zhang
Journal:  Exp Ther Med       Date:  2014-10-31       Impact factor: 2.447

Review 6.  Advances in genetic studies of substance abuse in China.

Authors:  Yan Sun; Shiqiu Meng; Jiali Li; Jie Shi; Lin Lu
Journal:  Shanghai Arch Psychiatry       Date:  2013-08

7.  SLC6A4 STin2 VNTR genetic polymorphism is associated with tobacco use disorder, but not with successful smoking cessation or smoking characteristics: a case control study.

Authors:  Márcia Regina Pizzo de Castro; Michael Maes; Roberta Losi Guembarovski; Carolina Batista Ariza; Edna Maria Vissoci Reiche; Heber Odebrecht Vargas; Mateus Medonça Vargas; Luiz Gustavo Piccoli de Melo; Seetal Dodd; Michael Berk; Maria Angelica Ehara Watanabe; Sandra Odebrecht Vargas Nunes
Journal:  BMC Genet       Date:  2014-06-27       Impact factor: 2.797
  7 in total

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