| Literature DB >> 21676612 |
Amanda C Allan1, Andy Billinton, Susan H Brown, Anita Chowdhury, Andrew J Eatherton, Charlotte Fieldhouse, Gerard M P Giblin, Paul Goldsmith, Adrian Hall, David N Hurst, Alan Naylor, D Anthony Rawlings, Mairi Sime, Tiziana Scoccitti, Pamela J Theobald.
Abstract
We describe the discovery and optimization of a novel series of benzofuran EP(1) antagonists, leading to the identification of 26d, a novel nonacidic EP(1) antagonist which demonstrated efficacy in preclinical models of chronic inflammatory pain.Entities:
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Year: 2011 PMID： 21676612 DOI： 10.1016/j.bmcl.2011.05.047
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823