Xiang Zhou1, Weiting Xu, Jianchang Chen. 1. Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, People's Republic of China.
Abstract
OBJECTIVE: The present study was designed to investigate the potential association between the 981C>T polymorphism in protein tyrosine phosphatase 1B (PTP-1B) and coronary artery disease (CAD). METHODS: We conducted a hospital-based case-control study with 864 CAD patients and 1008 controls to explore the association between the PTP-1B 981C>T polymorphism and risk of CAD in Chinese Han population. RESULTS: Subjects with the variant genotypes (CT+TT) had a 52% decreased risk of CAD relative to CC carriers (adjusted odds ratio, 0.48; 95% confidence interval, 0.39-0.60). The 981C>T polymorphism was associated with a higher body mass index and serum triglyceride levels in both CAD patients and controls. Moreover, this polymorphism was found to be associated with a lower serum glucose levels in cases, but not in controls. CONCLUSION: Our study demonstrates that the PTP-1B 981C>T polymorphism is associated with decreased risk of CAD in Chinese Han population.
OBJECTIVE: The present study was designed to investigate the potential association between the 981C>T polymorphism in protein tyrosine phosphatase 1B (PTP-1B) and coronary artery disease (CAD). METHODS: We conducted a hospital-based case-control study with 864 CAD patients and 1008 controls to explore the association between the PTP-1B 981C>T polymorphism and risk of CAD in Chinese Han population. RESULTS: Subjects with the variant genotypes (CT+TT) had a 52% decreased risk of CAD relative to CC carriers (adjusted odds ratio, 0.48; 95% confidence interval, 0.39-0.60). The 981C>T polymorphism was associated with a higher body mass index and serum triglyceride levels in both CAD patients and controls. Moreover, this polymorphism was found to be associated with a lower serum glucose levels in cases, but not in controls. CONCLUSION: Our study demonstrates that the PTP-1B 981C>T polymorphism is associated with decreased risk of CAD in Chinese Han population.
Authors: Alexey A Lagunin; Sergey M Ivanov; Tatyana A Gloriozova; Pavel V Pogodin; Dmitry A Filimonov; Sandeep Kumar; Rajesh K Goel Journal: Sci Rep Date: 2020-01-14 Impact factor: 4.379