Literature DB >> 21675776

Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors.

Lidia Martín-Couce1, Mar Martín-Fontecha, Samanta Capolicchio, María L López-Rodríguez, Silvia Ortega-Gutiérrez.   

Abstract

We report the synthesis of new chemical probes (1a,b, 2a-c, 3a-c) based on the structure of the main endocannabinoids for their use in biological systems directly or via click chemistry. As proof of concept, 2-arachidonyl glyceryl ether based biotinylated 3b enables direct visualization of CB(1) receptor in cells. These results represent the starting point for the development of advanced small molecule chemical probes able to generate valuable information about the cannabinoid receptors.

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Year:  2011        PMID： 21675776     DOI： 10.1021/jm2004392

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  4 in total

1.  Mitochondrial CB₁ receptors regulate neuronal energy metabolism.

Authors:  Giovanni Bénard; Federico Massa; Nagore Puente; Joana Lourenço; Luigi Bellocchio; Edgar Soria-Gómez; Isabel Matias; Anna Delamarre; Mathilde Metna-Laurent; Astrid Cannich; Etienne Hebert-Chatelain; Christophe Mulle; Silvia Ortega-Gutiérrez; Mar Martín-Fontecha; Matthias Klugmann; Stephan Guggenhuber; Beat Lutz; Jürg Gertsch; Francis Chaouloff; María Luz López-Rodríguez; Pedro Grandes; Rodrigue Rossignol; Giovanni Marsicano
Journal:  Nat Neurosci       Date:  2012-03-04       Impact factor: 24.884

2.  On the cellular metabolism of the click chemistry probe 19-alkyne arachidonic acid.

Authors:  Philippe Pierre Robichaud; Samuel J Poirier; Luc H Boudreau; Jérémie A Doiron; David A Barnett; Eric Boilard; Marc E Surette
Journal:  J Lipid Res       Date:  2016-08-18       Impact factor: 5.922

3.  Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells.

Authors:  Marjolein Soethoudt; Sara C Stolze; Matthias V Westphal; Luuk van Stralen; Andrea Martella; Eva J van Rooden; Wolfgang Guba; Zoltan V Varga; Hui Deng; Sander I van Kasteren; Uwe Grether; Adriaan P IJzerman; Pal Pacher; Erick M Carreira; Herman S Overkleeft; Andreea Ioan-Facsinay; Laura H Heitman; Mario van der Stelt
Journal:  J Am Chem Soc       Date:  2018-02-16       Impact factor: 15.419

Review 4.  Functionalized Cannabinoid Subtype 2 Receptor Ligands: Fluorescent, PET, Photochromic and Covalent Molecular Probes.

Authors:  Filippo Basagni; Michela Rosini; Michael Decker
Journal:  ChemMedChem       Date:  2020-06-24       Impact factor: 3.466
  4 in total

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