OBJECTIVE: Atherosclerosis has been implicated in the development of brain atrophy. However, support for this association comes from cross-sectional studies. METHODS: Within the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study, a prospective cohort study among patients with symptomatic atherosclerotic disease (mean age ± standard deviation, 58 ± 10 years; 80% men), magnetic resonance imaging of the brain was performed in 1,232 patients at baseline (2001-2005) and in 663 patients at follow-up (2006-2009). Brain segmentation was used to quantify total brain volume, cortical gray matter volume, and ventricular volume as indicators of global, cortical, and subcortical atrophy. At baseline, measurements of carotid intima-media thickness (CIMT) and carotid stenosis were performed. Carotid stenosis was classified into groups 0 of 50%, 50 of 70% (moderate), and >70% (severe) and into unilateral or bilateral stenosis. RESULTS: Cross-sectional regression analyses showed that both increased CIMT and carotid stenosis were associated with decreased relative total brain and cortical gray matter volume. Our prospective findings showed that after a mean follow-up of 3.9 years (range, 3.0-5.8 years), CIMT and moderate stenosis were not related to progression of brain atrophy. Only severe or bilateral carotid stenosis was related to progression of global atrophy (β [95% confidence interval (CI)], -0.52% [-0.84 to -0.20%], -0.94% [-1.45 to -0.43%]), cortical atrophy (β [95% CI], -0.75% [-1.37 to -0.13%], -1.34% [-2.32 to -0.35%]), and subcortical atrophy (β [95% CI], 0.06% [-0.02 to 0.16%], 0.13% [0.01 to 0.28%]). INTERPRETATION: In a study of patients with atherosclerotic disease with 4 years of follow-up, only severe or bilateral carotid stenosis, and not moderate carotid stenosis and increased CIMT, were associated with progression of brain atrophy.
OBJECTIVE:Atherosclerosis has been implicated in the development of brain atrophy. However, support for this association comes from cross-sectional studies. METHODS: Within the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study, a prospective cohort study among patients with symptomatic atherosclerotic disease (mean age ± standard deviation, 58 ± 10 years; 80% men), magnetic resonance imaging of the brain was performed in 1,232 patients at baseline (2001-2005) and in 663 patients at follow-up (2006-2009). Brain segmentation was used to quantify total brain volume, cortical gray matter volume, and ventricular volume as indicators of global, cortical, and subcortical atrophy. At baseline, measurements of carotid intima-media thickness (CIMT) and carotid stenosis were performed. Carotid stenosis was classified into groups 0 of 50%, 50 of 70% (moderate), and >70% (severe) and into unilateral or bilateral stenosis. RESULTS: Cross-sectional regression analyses showed that both increased CIMT and carotid stenosis were associated with decreased relative total brain and cortical gray matter volume. Our prospective findings showed that after a mean follow-up of 3.9 years (range, 3.0-5.8 years), CIMT and moderate stenosis were not related to progression of brain atrophy. Only severe or bilateral carotid stenosis was related to progression of global atrophy (β [95% confidence interval (CI)], -0.52% [-0.84 to -0.20%], -0.94% [-1.45 to -0.43%]), cortical atrophy (β [95% CI], -0.75% [-1.37 to -0.13%], -1.34% [-2.32 to -0.35%]), and subcortical atrophy (β [95% CI], 0.06% [-0.02 to 0.16%], 0.13% [0.01 to 0.28%]). INTERPRETATION: In a study of patients with atherosclerotic disease with 4 years of follow-up, only severe or bilateral carotid stenosis, and not moderate carotid stenosis and increased CIMT, were associated with progression of brain atrophy.
Authors: Kathy F Yates; Victoria Sweat; Po Lai Yau; Michael M Turchiano; Antonio Convit Journal: Arterioscler Thromb Vasc Biol Date: 2012-09 Impact factor: 8.311
Authors: Valerie A Cardenas; Bruce Reed; Linda L Chao; Helena Chui; Nerses Sanossian; Charles C DeCarli; Wendy Mack; Joel Kramer; Howard N Hodis; Mingzhu Yan; Michael H Buonocore; Owen Carmichael; William J Jagust; Michael W Weiner Journal: Stroke Date: 2012-09-13 Impact factor: 7.914
Authors: Michael L Alosco; Adam M Brickman; Mary Beth Spitznagel; Erica Y Griffith; Atul Narkhede; Naftali Raz; Ronald Cohen; Lawrence H Sweet; Joel Hughes; Jim Rosneck; John Gunstad Journal: J Am Soc Hypertens Date: 2013-06-02
Authors: Maarten Ht Zwartbol; Anja G van der Kolk; Hugo J Kuijf; Theo D Witkamp; Rashid Ghaznawi; Jeroen Hendrikse; Mirjam I Geerlings Journal: J Cereb Blood Flow Metab Date: 2020-10-06 Impact factor: 6.200