Literature DB >> 2167238

Mutual dependence of Na,K-ATPase alpha- and beta-subunits for correct posttranslational processing and intracellular transport.

U Ackermann1, K Geering.   

Abstract

In this study, we have followed the fate of newly synthesized alpha- and beta-subunits of Na,K-ATPase in Xenopus oocytes injected with alpha and/or beta cRNA to examine whether assembly of the two subunits is needed for a correct folding and/or for intracellular transport of Na,K-ATPase. Our data indicate that (1) assembly of alpha- and beta-subunits occurs at the level of the ER, (2) beta-subunits are needed for the newly synthesized alpha-subunit to adopt a stable configuration and (3) alpha- and beta-subunits mutually depend on each other to be transported out of the ER.

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Year:  1990        PMID： 2167238     DOI： 10.1016/0014-5793(90)81130-g

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  44 in total

1.  Endoplasmic reticulum quality control of oligomeric membrane proteins: topogenic determinants involved in the degradation of the unassembled Na,K-ATPase alpha subunit and in its stabilization by beta subunit assembly.

Authors:  P Béguin; U Hasler; O Staub; K Geering
Journal:  Mol Biol Cell       Date:  2000-05       Impact factor: 4.138

Review 2.  The functional role of beta subunits in oligomeric P-type ATPases.

Authors:  K Geering
Journal:  J Bioenerg Biomembr       Date:  2001-10       Impact factor: 2.945

3.  Overexpression of the erythrocyte plasma membrane Ca2+ pump in COS-1 cells.

Authors:  H P Adamo; A K Verma; M A Sanders; R Heim; J L Salisbury; E D Wieben; J T Penniston
Journal:  Biochem J       Date:  1992-08-01       Impact factor: 3.857

4.  High-affinity ouabain binding by yeast cells expressing Na+, K(+)-ATPase alpha subunits and the gastric H+, K(+)-ATPase beta subunit.

Authors:  K A Eakle; K S Kim; M A Kabalin; R A Farley
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-01       Impact factor: 11.205

5.  Na,K-ATPase beta1-subunit increases the translation efficiency of the alpha1-subunit in MSV-MDCK cells.

Authors:  Sigrid A Rajasekaran; Jegan Gopal; Dianna Willis; Cromwell Espineda; Jeffery L Twiss; Ayyappan K Rajasekaran
Journal:  Mol Biol Cell       Date:  2004-05-07       Impact factor: 4.138

Review 6.  Na(+),K (+)-ATPase as a docking station: protein-protein complexes of the Na(+),K (+)-ATPase.

Authors:  Linda Reinhard; Henning Tidow; Michael J Clausen; Poul Nissen
Journal:  Cell Mol Life Sci       Date:  2012-06-14       Impact factor: 9.261

7.  Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases.

Authors:  Lieke M van der Velden; Catharina G K Wichers; Adriana E D van Breevoort; Jonathan A Coleman; Robert S Molday; Ruud Berger; Leo W J Klomp; Stan F J van de Graaf
Journal:  J Biol Chem       Date:  2010-10-14       Impact factor: 5.157

8.  Ion dependence of Na-K-ATPase-mediated epithelial cell adhesion and migration.

Authors:  Sona Lakshme Balasubramaniam; Anilkumar Gopalakrishnapillai; Sonali P Barwe
Journal:  Am J Physiol Cell Physiol       Date:  2015-07-08       Impact factor: 4.249

9.  Repositioning of Somatic Golgi Apparatus Is Essential for the Dendritic Establishment of Adult-Born Hippocampal Neurons.

Authors:  Sneha Rao; Gregory W Kirschen; Joanna Szczurkowska; Adrian Di Antonio; Jia Wang; Shaoyu Ge; Maya Shelly
Journal:  J Neurosci       Date:  2017-12-07       Impact factor: 6.167

10.  Aldosterone modulates sodium kinetics of Na,K-ATPase containing an alpha 1 subunit in A6 kidney cell epithelia.

Authors:  J Beron; L Mastroberardino; A Spillmann; F Verrey
Journal:  Mol Biol Cell       Date:  1995-03       Impact factor: 4.138
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