| Literature DB >> 2167111 |
Abstract
Our model proposes that topoisomerase-targeting antitumor drugs form reversible drug-enzyme-DNA complexes that collide with the DNA and RNA synthesis machineries. On collision, the complexes lose their reversibility, and generate lethal double-strand DNA breaks. Further investigations of topoisomerase action will allow this model to be refined, and may ultimately lead to the development of more effective anticancer drugs.Entities:
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Year: 1990 PMID： 2167111
Source DB: PubMed Journal: Cancer Cells ISSN： 1042-2196