Literature DB >> 21669942

Applications of post-translational modifications of FoxO family proteins in biological functions.

Ying Zhao1, Yachen Wang, Wei-Guo Zhu.   

Abstract

The functions of the FoxO family proteins, in particular their transcriptional activities, are modulated by post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, methylation and glycosylation. These PTMs occur in response to different cellular stresses, which in turn regulate the subcellular localization of FoxO family proteins, as well as their half-life, DNA binding, transcriptional activity and ability to interact with other cellular proteins. In this review, we summarize the role of PTMs of FoxO family proteins in linking their biological and functional relevance with various diseases.

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Year:  2011        PMID： 21669942     DOI： 10.1093/jmcb/mjr013

Source DB:  PubMed          Journal:  J Mol Cell Biol        ISSN： 1759-4685            Impact factor:   6.216


  92 in total

1.  Effects of ageing on expression of the muscle-specific E3 ubiquitin ligases and Akt-dependent regulation of Foxo transcription factors in skeletal muscle.

Authors:  Akira Wagatsuma; Masataka Shiozuka; Yuzo Takayama; Takayuki Hoshino; Kunihiko Mabuchi; Ryoichi Matsuda
Journal:  Mol Cell Biochem       Date:  2015-11-20       Impact factor: 3.396

2.  Mitochondrial FOXO3a is involved in amyloid β peptide-induced mitochondrial dysfunction.

Authors:  Chun Shi; Jianhua Zhu; Shuilong Leng; Dahong Long; Xiumei Luo
Journal:  J Bioenerg Biomembr       Date:  2016-01-19       Impact factor: 2.945

3.  Methylation of FoxO3 regulates neuronal cell death.

Authors:  Wei-guo Zhu
Journal:  Acta Pharmacol Sin       Date:  2012-05       Impact factor: 6.150

4.  Interleukin-4 induces up-regulation of endothelial cell claudin-5 through activation of FoxO1: role in protection from complement-mediated injury.

Authors:  Agustin P Dalmasso; Daniel Goldish; Barbara A Benson; Alexander K Tsai; Karen R Wasiluk; Gregory M Vercellotti
Journal:  J Biol Chem       Date:  2013-11-26       Impact factor: 5.157

5.  Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3-Independent T Cells with Suppressive Properties.

Authors:  Inna V Grishkan; Dominique M Tosi; Melissa D Bowman; Maya Harary; Peter A Calabresi; Anne R Gocke
Journal:  J Immunol       Date:  2015-07-06       Impact factor: 5.422

Review 6.  Human T-lymphotropic virus proteins and post-translational modification pathways.

Authors:  Carlo Bidoia
Journal:  World J Virol       Date:  2012-08-12

7.  Doxorubicin induces cardiomyocyte apoptosis and atrophy through cyclin-dependent kinase 2-mediated activation of forkhead box O1.

Authors:  Peng Xia; Jingrui Chen; Yuening Liu; Maya Fletcher; Brian C Jensen; Zhaokang Cheng
Journal:  J Biol Chem       Date:  2020-02-19       Impact factor: 5.157

Review 8.  Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a.

Authors:  Feng Wang; Christopher B Marshall; Mitsuhiko Ikura
Journal:  Intrinsically Disord Proteins       Date:  2015-06-03

9.  The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity.

Authors:  Thomas Heimbucher; Zheng Liu; Carine Bossard; Richard McCloskey; Andrea C Carrano; Christian G Riedel; Bogdan Tanasa; Christian Klammt; Bryan R Fonslow; Celine E Riera; Bjorn F Lillemeier; Kenneth Kemphues; John R Yates; Clodagh O'Shea; Tony Hunter; Andrew Dillin
Journal:  Cell Metab       Date:  2015-07-07       Impact factor: 27.287

10.  Gonadal expression of Foxo1, but not Foxo3, is conserved in diverse Mammalian species.

Authors:  Edward D Tarnawa; Michael D Baker; Gina M Aloisio; Bruce R Carr; Diego H Castrillon
Journal:  Biol Reprod       Date:  2013-04-25       Impact factor: 4.285
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