| Literature DB >> 21669521 |
Chris De Savi1, Andrew D Morley, Attilla Ting, Ian Nash, Kostas Karabelas, Christine M Wood, Michael James, Stephen J Norris, Galith Karoutchi, Neil Rankine, Gordon Hamlin, Philip A Macfaul, David Ryan, Sarah V Baker, David Hargreaves, Stefan Gerhardt.
Abstract
Directed screening has identified a novel series of MMP13 inhibitors that possess good levels of activity whilst possessing excellent selectivity over related MMPs. The binding mode of the series has been solved by co-crystallisation and demonstrates an interesting mode of inhibition without interaction with the catalytic zinc atom.Entities:
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Year: 2011 PMID： 21669521 DOI： 10.1016/j.bmcl.2011.05.075
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823