OBJECTIVE: To assess the discrepancy between width of surgical margin measured with the naked eye/ruler by a surgeon before removing an invasive vulvar carcinoma, and width of margin measured under microscope by pathologist after fixation of the resected lesion with formalin. Potential relationships between discrepancy and disease recurrence were also investigated. METHODS: This prospective study was conducted with resected lesions from 86 women who underwent surgery for primary/recurrent invasive vulvar carcinoma. After the surgeon removed the lesions surrounded by 1-2-cm margins, the pathologist determined margin width at the 4 cardinal points of 86 lesions (for a total of 344 margin assessments), first macroscopically and then under the microscope. RESULTS: A safety margin of 0.8 cm on microscopic view was achieved in 83% of cases (112 of 135) when the macroscopic measurement was 1cm, in 91% of cases (58 of 64) when it was 1.5 cm, and 98% of cases (105 of 107) when it was 2 cm. CONCLUSION: There was a small discrepancy between the surgeon's intent and the microscopic margin measurement, mostly related to tissue shrinkage. A 1-cm surgical margin corresponded to a 0.8-cm margin in microscopic view (the "safe margin") in most cases.
OBJECTIVE: To assess the discrepancy between width of surgical margin measured with the naked eye/ruler by a surgeon before removing an invasive vulvar carcinoma, and width of margin measured under microscope by pathologist after fixation of the resected lesion with formalin. Potential relationships between discrepancy and disease recurrence were also investigated. METHODS: This prospective study was conducted with resected lesions from 86 women who underwent surgery for primary/recurrent invasive vulvar carcinoma. After the surgeon removed the lesions surrounded by 1-2-cm margins, the pathologist determined margin width at the 4 cardinal points of 86 lesions (for a total of 344 margin assessments), first macroscopically and then under the microscope. RESULTS: A safety margin of 0.8 cm on microscopic view was achieved in 83% of cases (112 of 135) when the macroscopic measurement was 1cm, in 91% of cases (58 of 64) when it was 1.5 cm, and 98% of cases (105 of 107) when it was 2 cm. CONCLUSION: There was a small discrepancy between the surgeon's intent and the microscopic margin measurement, mostly related to tissue shrinkage. A 1-cm surgical margin corresponded to a 0.8-cm margin in microscopic view (the "safe margin") in most cases.
Authors: Thu Tran; Chandru P Sundaram; Clinton D Bahler; John N Eble; David J Grignon; M Francesca Monn; Novae B Simper; Liang Cheng Journal: J Cancer Date: 2015-07-02 Impact factor: 4.207
Authors: Jan Heidkamp; Petra L M Zusterzeel; Adriana C H van Engen-van Grunsven; Christiaan G Overduin; Andor Veltien; Arie Maat; Maroeska M Rovers; Jurgen J Fütterer Journal: NMR Biomed Date: 2018-11-15 Impact factor: 4.044
Authors: Sara Iacoponi; Ignacio Zapardiel; Maria Dolores Diestro; Alicia Hernandez; Javier De Santiago Journal: J Gynecol Oncol Date: 2013-07-04 Impact factor: 4.401