| Literature DB >> 21669392 |
Anna Figueiredo1, Thomas J Hope.
Abstract
Integration of reverse transcribed HIV-1 DNA into the host genome, catalyzed by HIV-1 integrase, represents an obligate step in establishing productive viral infection. Allouch et al. (2011) identify KAP1 (TRIM28) as an interaction partner of acetylated integrase. KAP1, in complex with HDAC1, represses HIV-1 integration through specific deacetylation of HIV-1 integrase.Entities:
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Year: 2011 PMID： 21669392 DOI： 10.1016/j.chom.2011.05.009
Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023