| Literature DB >> 2166920 |
A J Sleight1, A Cervenka, S J Peroutka.
Abstract
The effect of sumatriptan, a selective 5-HT1D receptor agent, on extracellular levels of 5-HT in the frontal cortex of the guinea pig was measured by intracerebral dialysis. A constant infusion of sumatriptan (10(-8)-10(-7) M) dose-dependently reduced extracellular levels of 5-HT (e.g. 80 +/- 2% decrease from control levels of 5-HT at 10(-7) M). Peripheral administration of sumatriptan (50 micrograms/kg i.p. and 500 micrograms/kg i.p.) had no effect on extracellular levels of 5-HT in the frontal cortex. These data suggest that sumatriptan, when infused into the brain, inhibits the release of 5-HT by stimulating 5-HT autoreceptors and that the putative acute anti-migraine effects of sumatriptan are likely to be mediated by peripheral mechanisms.Entities:
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Year: 1990 PMID： 2166920 DOI： 10.1016/0028-3908(90)90061-u
Source DB: PubMed Journal: Neuropharmacology ISSN： 0028-3908 Impact factor: 5.250