| Literature DB >> 21668824 |
Victoria Maneu1, Alberto Yáñez, Celia Murciano, Andrés Molina, María Luisa Gil, Daniel Gozalbo.
Abstract
We have investigated the expression of TLR2 and Dectin-1 in retinal microglia and their involvement in Candida albicans phagocytosis using a cytometric approach. The expression of both receptors has been demonstrated in CD11b(+) retinal cells. Phagocytosis of pHrodo-labelled C. albicans yeasts by microglial CD11b(+) cells of C57BL/6 mice was inhibited both by the Dectin-1 antagonist laminarin and anti-Dectin-1 antibodies, whereas phagocytosis of yeasts by retinal microglia of TLR2 KO mice was unaffected. These data indicate that phagocytosis of C. albicans yeasts by retinal microglia is mediated by Dectin-1, whereas TLR2 does not play a significant role in this process.Entities:
Mesh：
Substances：
Year: 2011 PMID： 21668824 DOI： 10.1111/j.1574-695X.2011.00829.x
Source DB: PubMed Journal: FEMS Immunol Med Microbiol ISSN： 0928-8244