| Literature DB >> 21668797 |
Arpana Agrawal1, Michael T Lynskey, Anthony Hinrichs, Richard Grucza, Scott F Saccone, Robert Krueger, Rosalind Neuman, William Howells, Sherri Fisher, Louis Fox, Robert Cloninger, Danielle M Dick, Kimberly F Doheny, Howard J Edenberg, Alison M Goate, Victor Hesselbrock, Eric Johnson, John Kramer, Samuel Kuperman, John I Nurnberger, Elizabeth Pugh, Marc Schuckit, Jay Tischfield, John P Rice, Kathleen K Bucholz, Laura J Bierut.
Abstract
Despite twin studies showing that 50-70% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genome-wide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis-dependent cases with 2346 cannabis-exposed non-dependent controls was conducted using logistic regression in PLINK. None of the 948 142 single nucleotide polymorphisms met genome-wide significance (P at E-8). The lowest P values were obtained for polymorphisms on chromosome 17 (rs1019238 and rs1431318, P values at E-7) in the ANKFN1 gene. While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence.Entities:
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Year: 2010 PMID： 21668797 PMCID： PMC3117436 DOI： 10.1111/j.1369-1600.2010.00255.x
Source DB: PubMed Journal: Addict Biol ISSN： 1355-6215 Impact factor: 4.280