BACKGROUND AND PURPOSE: Subthalamic nucleus deep brain stimulation (STN-DBS) has been shown to have beneficial effects on the motor features of Parkinson's disease (PD), but its impact on non-motor symptoms, most notably mood, has not been fully explored. METHODS: In the first study to independently compare the emotional-cognitive and somatic/physiological symptoms of depression, we examined mood differences in 17 bilateral STN-DBS and 22 matched non-surgical PD patients at baseline and 6 months. RESULTS: The STN-DBS group reported higher levels of depression at baseline with significant endorsement of physical symptomatology. Postoperatively, no significant between-group differences in physical symptoms of depression were found. In contrast, a significant group by time interaction for cognitive-emotional symptoms of depression was found, with the STN-DBS group reporting an increase in psychological symptoms of distress. The STN-DBS group also reported an increase in anxiety following surgery. The suicide rate of 5% found in our study is consistent with other postoperative studies in PD. The impact of changes in levodopa and psychotropic medication are also explored. CONCLUSIONS: Preliminary results suggest that the motor improvement often observed in patients with PD following bilateral STN-DBS may be partially offset by an increase in affective-cognitive symptoms of depression.
BACKGROUND AND PURPOSE: Subthalamic nucleus deep brain stimulation (STN-DBS) has been shown to have beneficial effects on the motor features of Parkinson's disease (PD), but its impact on non-motor symptoms, most notably mood, has not been fully explored. METHODS: In the first study to independently compare the emotional-cognitive and somatic/physiological symptoms of depression, we examined mood differences in 17 bilateral STN-DBS and 22 matched non-surgical PDpatients at baseline and 6 months. RESULTS: The STN-DBS group reported higher levels of depression at baseline with significant endorsement of physical symptomatology. Postoperatively, no significant between-group differences in physical symptoms of depression were found. In contrast, a significant group by time interaction for cognitive-emotional symptoms of depression was found, with the STN-DBS group reporting an increase in psychological symptoms of distress. The STN-DBS group also reported an increase in anxiety following surgery. The suicide rate of 5% found in our study is consistent with other postoperative studies in PD. The impact of changes in levodopa and psychotropic medication are also explored. CONCLUSIONS: Preliminary results suggest that the motor improvement often observed in patients with PD following bilateral STN-DBS may be partially offset by an increase in affective-cognitive symptoms of depression.
Authors: Tomas Cartmill; David Skvarc; Richard Bittar; Jane McGillivray; Michael Berk; Linda K Byrne Journal: Neuropsychol Rev Date: 2021-02-19 Impact factor: 7.444
Authors: Amit Chopra; Osama A Abulseoud; Shirlene Sampson; Kendall H Lee; Bryan T Klassen; Julie A Fields; Joseph Y Matsumoto; Andrea C Adams; Cynthia J Stoppel; Jennifer R Geske; Mark A Frye Journal: Psychosomatics Date: 2013-12-21 Impact factor: 2.386
Authors: Melissa Deanna Shepard; Kate Perepezko; Martijn P G Broen; Jared Thomas Hinkle; Ankur Butala; Kelly A Mills; Julie Nanavati; Nicole Mercado Fischer; Paul Nestadt; Gregory Pontone Journal: J Neurol Neurosurg Psychiatry Date: 2019-01-19 Impact factor: 10.154
Authors: Maria Ironside; Ken-Ichi Amemori; Callie L McGrath; Mads Lund Pedersen; Min Su Kang; Satoko Amemori; Michael J Frank; Ann M Graybiel; Diego A Pizzagalli Journal: Biol Psychiatry Date: 2019-09-06 Impact factor: 13.382
Authors: Mehmet Utku Kucuker; Ammar G Almorsy; Ayse Irem Sonmez; Anna N Ligezka; Deniz Doruk Camsari; Charles P Lewis; Paul E Croarkin Journal: Front Hum Neurosci Date: 2021-06-25 Impact factor: 3.169