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Literature DB >> 2166834

Site of reovirus replication in liver is determined by the type of hepatocellular insult.

D H Rubin¹, A H Morrison, C L Witzleben, C J Guico, D A Piccoli.

Abstract

Reovirus type 1 strain Lang is restricted from replicating in adult murine livers. In noninjured livers, approximately 1% of hepatocytes express reovirus antigen during infection. However, hepatocytes can be induced to express reovirus antigen if challenged with either toxins or trauma. We used selective hepatotoxins or surgical trauma to demonstrate that reovirus antigen localization in liver is determined by the site of hepatocellular insult and the timing of the virus inoculum.

Entities: Disease Species

Mesh：

Substances：
Antigens, Viral

Year: 1990 PMID： 2166834 PMCID： PMC247936 DOI： 10.1128/JVI.64.9.4593-4597.1990

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

22 in total

1. Emerging concept of poliomyelitis infection.

Authors: D BODIAN
Journal: Science Date: 1955-07-15 Impact factor: 47.728

2. Acute poliomyelitis relation of physical activity at the time of onset to the course of the disease.

Authors: D M HORSTMANN
Journal: J Am Med Assoc Date: 1950-01-28

3. Genome RNAs and polypeptides of reovirus serotypes 1, 2, and 3.

Authors: R F Ramig; R K Cross; B N Fields
Journal: J Virol Date: 1977-06 Impact factor: 5.103

4. Structural similarities between the mammalian beta-adrenergic and reovirus type 3 receptors.

Authors: M S Co; G N Gaulton; A Tominaga; C J Homcy; B N Fields; M I Greene
Journal: Proc Natl Acad Sci U S A Date: 1985-08 Impact factor: 11.205

5. Polypeptide components of virions, top component and cores of reovirus type 3.

Authors: R E Smith; H J Zweerink; W K Joklik
Journal: Virology Date: 1969-12 Impact factor: 3.616

6. Studies on the effect of chymotrypsin on reovirions.

Authors: W K Joklik
Journal: Virology Date: 1972-09 Impact factor: 3.616

7. Transport of infectious reovirus into bile: class II major histocompatibility antigen-bearing cells determine reovirus transport.

Authors: D H Rubin; T Costello; C L Witzleben; M I Greene
Journal: J Virol Date: 1987-10 Impact factor: 5.103

2. Characterization of cytotoxic cells from reovirus-infected SCID mice: activated cells express natural killer- and lymphokine-activated killer-like activity but fail to clear infection.

Authors: J Taterka; J J Cebra; D H Rubin
Journal: J Virol Date: 1995-06 Impact factor: 5.103

2 in total

Site of reovirus replication in liver is determined by the type of hepatocellular insult.

1. Emerging concept of poliomyelitis infection.

2. Acute poliomyelitis relation of physical activity at the time of onset to the course of the disease.

3. Genome RNAs and polypeptides of reovirus serotypes 1, 2, and 3.

4. Structural similarities between the mammalian beta-adrenergic and reovirus type 3 receptors.

5. Polypeptide components of virions, top component and cores of reovirus type 3.

6. Studies on the effect of chymotrypsin on reovirions.

7. Transport of infectious reovirus into bile: class II major histocompatibility antigen-bearing cells determine reovirus transport.

8. Comparative studies of biliary atresia in the human newborn and reovirus-induced cholangitis in weanling mice.

9. Early changes in bile duct lining cells and hepatocytes in rats treated with alpha-naphthylisothiocyanate.

10. Histological demonstration of wheat germ lectin binding sites in the liver of normal and ANIT treated rats.

1. Selective reovirus infection of murine hepatocarcinoma cells during cell division. A model of viral liver infection.

2. Characterization of cytotoxic cells from reovirus-infected SCID mice: activated cells express natural killer- and lymphokine-activated killer-like activity but fail to clear infection.