Literature DB >> 2166833

Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells.

J S Williamson1, S A Stohlman.   

Abstract

Both CD4+ and CD8+ T cells are required for the clearance of virus from the central nervous system following infection with the JHM strain of mouse hepatitis virus. Development of antiviral antibodies requires the presence of CD4+ T cells but appears to play a minimal role in the reduction of virus. The data presented are consistent with the hypothesis that clearance of JHM virus is mediated by virus-specific CD8+ T cells, which appear to require the presence of CD4+ T cells.

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Year:  1990        PMID： 2166833      PMCID： PMC247935          DOI： 10.1128/JVI.64.9.4589-4592.1990

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  17 in total

1.  In vivo effects of coronavirus-specific T cell clones: DTH inducer cells prevent a lethal infection but do not inhibit virus replication.

Authors:  S A Stohlman; G K Matsushima; N Casteel; L P Weiner
Journal:  J Immunol       Date:  1986-04-15       Impact factor: 5.422

2.  T-cell-mediated clearance of mouse hepatitis virus strain JHM from the central nervous system.

Authors:  M A Sussman; R A Shubin; S Kyuwa; S A Stohlman
Journal:  J Virol       Date:  1989-07       Impact factor: 5.103

3.  Pathogenesis of demyelination induced by a mouse hepatitis.

Authors:  L P Weiner
Journal:  Arch Neurol       Date:  1973-05

4.  T4+ T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses.

Authors:  R Ahmed; L D Butler; L Bhatti
Journal:  J Virol       Date:  1988-06       Impact factor: 5.103

5.  Protective effect of monoclonal antibodies on lethal mouse hepatitis virus infection in mice.

Authors:  K Nakanaga; K Yamanouchi; K Fujiwara
Journal:  J Virol       Date:  1986-07       Impact factor: 5.103

6.  Mechanism of demyelination in JHM virus encephalomyelitis. Electron microscopic studies.

Authors:  P W Lampert; J K Sims; A J Kniazeff
Journal:  Acta Neuropathol       Date:  1973-03-30       Impact factor: 17.088

7.  In vivo and in vitro models of demyelinating disease: endogenous factors influencing demyelinating disease caused by mouse hepatitis virus in rats and mice.

Authors:  O Sorensen; R Dugre; D Percy; S Dales
Journal:  Infect Immun       Date:  1982-09       Impact factor: 3.441

8.  Chronic central nervous system demyelination in mice after JHM virus infection.

Authors:  S A Stohlman; L P Weiner
Journal:  Neurology       Date:  1981-01       Impact factor: 9.910

9.  Selective localization of wild type and mutant mouse hepatitis virus (JHM strain) antigens in CNS tissue by fluorescence, light and electron microscopy.

Authors:  R L Knobler; M Dubois-Dalcq; M V Haspel; A P Claysmith; P W Lampert; M B Oldstone
Journal:  J Neuroimmunol       Date:  1981-03       Impact factor: 3.478

10.  Studies on the mechanism of protection from acute viral encephalomyelitis by delayed-type hypersensitivity inducer T cell clones.

Authors:  S S Erlich; G K Matsushima; S A Stohlman
Journal:  J Neurol Sci       Date:  1989-04       Impact factor: 3.181
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  91 in total

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Authors:  Jeffrey M Zirger; Mariana Puntel; Josee Bergeron; Mia Wibowo; Rameen Moridzadeh; Niyati Bondale; Carlos Barcia; Kurt M Kroeger; Chunyan Liu; Maria G Castro; Pedro R Lowenstein
Journal:  Mol Ther       Date:  2012-01-10       Impact factor: 11.454

2.  CXCR4 signaling regulates remyelination by endogenous oligodendrocyte progenitor cells in a viral model of demyelination.

Authors:  Kevin S Carbajal; Juan L Miranda; Michelle R Tsukamoto; Thomas E Lane
Journal:  Glia       Date:  2011-08-09       Impact factor: 7.452

3.  CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus.

Authors:  Stephen A Stohlman; David R Hinton; Beatriz Parra; Roscoe Atkinson; Cornelia C Bergmann
Journal:  J Virol       Date:  2007-12-19       Impact factor: 5.103

4.  Disassociation between the in vitro and in vivo effects of nitric oxide on a neurotropic murine coronavirus.

Authors:  T E Lane; A D Paoletti; M J Buchmeier
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

5.  Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis.

Authors:  M T Lin; S A Stohlman; D R Hinton
Journal:  J Virol       Date:  1997-01       Impact factor: 5.103

6.  Population dynamics of lymphocyte subsets in the central nervous system of rats with different susceptibility to coronavirus-induced demyelinating encephalitis.

Authors:  R Dörries; S Schwender; H Imrich; H Harms
Journal:  Immunology       Date:  1991-11       Impact factor: 7.397

7.  Cross-protection against lymphocytic choriomeningitis virus mediated by a CD4+ T-cell clone specific for an envelope glycoprotein epitope of Lassa virus.

Authors:  V J La Posta; D D Auperin; R Kamin-Lewis; G A Cole
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103

8.  Central neuropathogenesis of vesicular stomatitis virus infection of immunodeficient mice.

Authors:  B S Huneycutt; Z Bi; C J Aoki; C S Reiss
Journal:  J Virol       Date:  1993-11       Impact factor: 5.103

9.  Microglia are required for protection against lethal coronavirus encephalitis in mice.

Authors:  D Lori Wheeler; Alan Sariol; David K Meyerholz; Stanley Perlman
Journal:  J Clin Invest       Date:  2018-01-29       Impact factor: 14.808

Review 10.  Coronaviruses post-SARS: update on replication and pathogenesis.

Authors:  Stanley Perlman; Jason Netland
Journal:  Nat Rev Microbiol       Date:  2009-06       Impact factor: 60.633
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